*SYNTHESIS AND PSYCHOTROPIC PROPERTIES OF AZOMETHINE dERIVATIVES OF tHIOPHENE

Article abstract of DOI:10.1007/BF01166328

A series of azomethine derivatives was obtained by condensation of 2-thiophenaldehyde and 5-substituted (alkyl, bromine, tert-butyl, trimethylsilyl)-2-thiophenaldehydes with semicarbazide, thiosemicarbazide, aminohydantoin and 2-semicarbazide acetic acid.Their psychotropic activity was investigated.It was found that incorporation of a tert-butyl group in position 5 of the thiophene ring potentiates the toxicity of the compound. 5-Trimethylsilyl- and 5-tetr-butyl-2-thiophenaldehyde thiosemicarbazones exhibit elevated neurotropic activity.These compounds cause the stimmulating effect of phenamine to appear, increasing the motor activity of animals by two times and prolonging the effect of hexenal-induced sleep.Substitution of thiosemicarbazone by semicarbazone decreases the activity except for hexenal sleep, where the 5-tert-butyl-2-thiophenaldehyde semicarbazone was 1.5 times more active than the thiosemicarbazone.