Catalytic Asymmetric Nitroaldol Reaction: An Efficient Synthesis of (S) Propranolol Using the Lanthanum Binaphthol Complex

Article abstract of DOI:10.1016/0040-4039(93)89031-K

(S) Propranolol, a more potent optical isomer of the widely used β-blocker, was conveniently synthesized in a highly enantioselective manner by the lanthanum-(R)-(+)-binaphthol complex catalyzed asymmetric nitroaldol reaction.