Bioorganic and Medicinal Chemistry Letters p. 1971 - 1976 (1996)
Update date:2022-08-10
Topics:
Jones, Graham B.
Kilgore, Michael W.
Pollenz, Richard S.
Li, Aiwen
Mathews, Jude E.
Wright, Justin M.
Huber, Robert S.
Tate, Patricia L.
Price, Thomas L.
Sticca, Robert P.
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
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