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InternationalJournalofPharmaceuticsxxx(xxxx)xxxx
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4. Conclusion
An active carrier platform was constructed based on the natural
product solanesol, which self-assembled to form micelles for the de-
livery of the anticancer drug DOX. In the case of STS, the tumor cell
survival rate was significantly reduced and the level of RAS protein was
also reduced. The amphiphilic mPEG-STS micelles were constructed to
efficiently load DOX and the acid-triggered drug release of the micelles
was realized by the incorporation of a hydrazone bond. The formed
mPEG-derived STS micelle structures alleviated the cytotoxicity caused
by STS, but long-term culture caused the destruction of the micelle
structures, and the link between mPEG and STS was broken, thereby
releasing the active group STS to function synergistically with the drug.
In addition, mPEG-derived STS micelles effectively reduced the ex-
pression levels of oncogene RAS and induced the occurrence of au-
tophagy negatively regulated by the RAS signaling pathway. In vivo
experiments also confirmed that mPEG-derived STS micelles effectively
inhibited tumor growth. The pharmacologically active solanesol deri-
vatives were used to construct a novel drug-loading system for deli-
vering anti-tumor drugs, which acted like the combination of the drugs
for tumor treatment. The mechanism of the synergistic anti-tumor effect
should be evaluated in future studies.
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Funding
This work was supported by the National Natural Science
Foundation of China [U1804176]; the key projects funded by the
Education Department of Henan Province [13A360054, 18A350005];
the key project funded by the Science and Technology Department of
Henan Province [182102210236].
Qin, S.Y., Zhang, A.Q., Cheng, S.X., Rong, L., Zhang, X.Z., 2017a. Drug self-delivery
Declaration of Competing Interest
Qu, Y., Chu, B.Y., Shi, K., Peng, J.R., Qian, Z.Y., 2017. Recent progress in functional
micellar carriers with intrinsic therapeutic activities for anticancer drug delivery. J.
Qin, B., Liu, L., Pan, Y., Zhu, Y., Wu, X., Song, S., Han, G., 2017b. PEGylated Solanesol for
Oral Delivery of Coenzyme Q 10. J. Agric. Food Chem. 65, 3360–3367. https://doi.
Qin, B., Liu, L., Wu, X., Liang, F., Hou, T., Pan, Y., Song, S., 2017c. mPEGylated solanesol
micelles as redox-responsive nanocarriers with synergistic anticancer effect. Acta
Qi, P., Wu, X., Liu, L., Yu, H., Song, S., 2018. Hydrazone-containing triblock copolymeric
micelles for pH-controlled drug delivery. Front. Pharmacol. 9, 1–11. https://doi.org/
The authors declare that they have no known competing financial
interests or personal relationships that could have appeared to influ-
ence the work reported in this paper.
Appendix A. Supplementary material
Supplementary data to this article can be found online at https://
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