A two step synthesis of the nucleoside Q precursor 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one (preQ(o))

Article abstract of DOI:10.1080/00397919608004641

PreQ(o) (1) is prepared in a 70% yield by the condensation of chloro(formyl)acetonitrile (2) with 2,6-diaminopyrimidin-4-one (3), and subsequently converted to its amide derivative 5. Isolation of the intermediate 4 in the condensation reaction was also observed giving further insight into the proposed mechanism.

Full text of DOI:10.1080/00397919608004641

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Synthetic Communications: An
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A Two Step Synthesis of the
Nucleoside Q Precursor 2-
Amino-5-cyanopyrrolo[2,3-
d]pyrimidin 4-one (PreQo)
Michael T. Migawa a b , Jack M. Hinkley a b , Geoffrey
C. Hoops a b & Leroy B. Townsend a b
a Department of Chemistry, College of Literature,
Science, and Arts, Ann Arbor, Michigan, 48109-1065
b Department of Medicinal Chemistry, College of
Pharmacy; The University of Michigan, Ann Arbor,
Michigan, 48109-1065
Version of record first published: 21 Aug 2006.
To cite this article: Michael T. Migawa , Jack M. Hinkley , Geoffrey C. Hoops &
Leroy B. Townsend (1996): A Two Step Synthesis of the Nucleoside Q Precursor 2-
Amino-5-cyanopyrrolo[2,3-d]pyrimidin 4-one (PreQo), Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 26:17,
3317-3322
To link to this article: http://dx.doi.org/10.1080/00397919608004641
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