Tetrahedron p. 1407 - 1416 (1992)
Update date:2022-08-11
Topics:
Kurth
Milco
Miller
We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), possess a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.
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Doi:10.1016/j.catcom.2019.01.006
(2019)Doi:10.1039/c6nj00321d
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(2020)Doi:10.1016/j.bmc.2017.05.052
(2017)Doi:10.1002/adsc.200600414
(2007)Doi:10.1080/00397910008087151
(2000)
