SYNTHESIS OF OPTICALLY PURE (R)- AND (S)-5-n-HEXADECANOLIDE. A PROPOSED PHEROMONE COMPONENT FROM ORIENTAL HORNET

Article abstract of DOI:10.1246/cl.1984.1935

Optically pure (R)- and (S)-5-n-hexadecanolide have been easily prepared by the reaction between optically active 1-bromo-3-tetrahydropyranyloxytetradecane (5) and lithium α-lithioacetate and the following lactonization. 5 was derived from optically pure 3-hydroxytetradecanoic acid obtained by the method reported before.