Photoactivated thiazole-based DNA-cleaving agents: Dramatic change of recognition sequence: Depending on the number of thiazole units

DOI: 10.1039/cc9960001825

Source and publish data:

Chemical Communications p. 1825 - 1826 (1996)

Update date:2022-08-29

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Authors:

Ninomiya

Satoh Satoh

Sugiyama

Shinomiya

Kuroda Kuroda

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Article abstract of DOI:10.1039/cc9960001825

By increasing the number of thiazole units in the photoactive DNA cleaving compounds, 4-(3-dimethylsulfoniopropyl- aminocarbonyl)-2-[2-(4-nitrobenzoylamino)ethyl]oligo-thiazole, from one or two to three, the specificity of their DNA cleavage was dramatically altered from 5'-AAATN-3' (N ≠ G) to 5'-GG-3'.

Full text of DOI:10.1039/cc9960001825

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