Chemistry of Heterocyclic Compounds p. 833 - 835 (1982)
Update date:2022-08-16
Topics:
El'chaninov, M. M.
Simonov, A. M.
Simkin, B. Ya.
The methyl group in 1-methyl-2-(5'-methyl-2'-hetaryl)benzimidazoles (hetaryl = furyl and thienyl) was oxidized.It was found that a salt of a carboxylic acid, which in an acidic medium loses carbon dioxide to give 1-methyl-2-(2'-furyl)-benzimidazole, is formed when 1-methyl-2-(5'-methyl-2'-furyl)benzimidazole is treated with an aqueous solution of potassium permanganate.The carboxy derivative of thiophene is considerably more stable.Oxidation by means of selenium dioxide leads to the corresponding 5'-formyl derivative.The structures of the compounds obtained were confirmed by data from the IR and PMR spectra.
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