Journal of the Chemical Society. Chemical communications p. 1416 - 1418 (1987)
Update date:2022-08-10
Topics:
Harnett, Sara P.
Lowe, Gordon
(Rp)-Deoxyadenosine 5'-<β-17O>-β-thiodiphosphate is hydrolysed in (18O)water at pH 7.2 (where it is present as its trianion) to AMP and inorganic <16O,17O,18O>thiophosphate with complete inversion of configuration at phosphorus, whereas at pH 4.5 (where it is present as its dianion) hydrolysis occurs with 50percent racemisation and 50percent inversion, indicating that 'liberated' metathiophosphate can exist and has a finite lifetime in aqueous solution under these conditions.
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