Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

Article abstract of DOI:10.1016/S0960-894X(99)00464-3

The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the paren