Journal of Pharmaceutical Sciences p. 776 - 781 (1983)
Update date:2022-08-30
Topics:
Yip
Li Wan Po
Irwin
The stability of hydrocortisone butyrate in semiaqueous and formulated gel systems has been investigated. It was shown that hydrocortisone butyrate underwent reversible isomerization to the C-21 ester of butyric acid. This ester then hydrolyzed to hydrocortisone, which in turn degraded to a complex mixture of compounds. This step is metal catalyzed and can be inhibited by the addition of EDTA [disodium(ethylenedinitrilo)tetraacetate]. The kinetics of decomposition is modeled using nonlinear regression analysis, and the rate constants for the various decomposition pathways are quantified.
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