A predicative model for certain directed metalations, IV; The dynamic behavior of the organolithio intermediates formed by metalation of p-dimethoxybenzene (p-DMB)

Article abstract of DOI:10.1016/0040-4039(95)01765-A

Significant disproportionation between the mono- and 2,5-bis-metalated intermediates resulting from metalation of p-DMB has been observed. The best procedure for the generation of each of these intermediates involves use of an "incremental" amount of TMEDA.¹.