Improved synthesis of N,N′-disuccinimidyl carbonate using α-pinene as acid scavenger

Article abstract of DOI:10.1080/00397910500281291

An improved synthesis of N,N′-disuccinimidyl carbonate (DSC) is described where α-pinene is utilized as an efficient scavenger of HCl liberated during the reaction of N-hydroxysuccinimide with triphosgene in THF. The α-pinene hydrochloride formed is soluble in THF and gives very pure DSC in good yields. Copyright Taylor & Francis, Inc.