Substituent effects on the conformational equilibrium of 1,3,5,7-cis-tetraoxadecalin systems: Force field calculations versus experimental results

Article abstract of DOI:10.1016/0957-4166(95)00366-W

Conformer populations of a number of 1,3,5,7-cis-tetraoxadecalins have been studied by ¹H NMR spectroscopy. While the unsubstituted 4 prefers the proximal conformation, all 4,8 disubstituted derivatives 5 preferred the distal conformation. This