Journal of the Chemical Society. Chemical communications p. 357 - 359 (1985)
Update date:2022-08-29
Topics:
Baldwin, Jack E.
Adlington, R. M.
Bohlmann, Rolf
A working chemical model for the carbon-sulphur bond formation step involved in penicillin biosynthesis is presented; thus, oxidation of a monocyclic β-lactam thiol, or its disulphide form, with dioxygen or hydrogen peroxide, catalysed by iron(II) ion, ascorbic acid, and ethylenediaminetetra-acetic acid, results in direct ring closure to penicillins as well as cephams, in a process similar to the enzymatic synthesis.
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