Journal of Medicinal Chemistry p. 1778 - 1780 (1983)
Update date:2022-08-11
Topics:
Demerson, Christopher A.
Humber, Leslie G.
Abraham, Nedumparambil A.
Schilling, Gunther
Martel, Rene R.
Pace-Asciak, Cecil
Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano<3,4-b>indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol.The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats.The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.
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