Journal of Medicinal Chemistry p. 1778 - 1780 (1983)
Update date:2022-08-11
Topics:
Demerson, Christopher A.
Humber, Leslie G.
Abraham, Nedumparambil A.
Schilling, Gunther
Martel, Rene R.
Pace-Asciak, Cecil
Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano<3,4-b>indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol.The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats.The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.
View More
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
Tangshan Moneide Trading Co., Ltd.
Contact:+86-315-8309571
Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Jinan Baozhao Pharmaceutical Co., Ltd
Contact:0086-531-86397156 82371858 82371868
Address:Huaneng Road, Jinan, Shandong ,China
Doi:10.1016/S0925-8388(03)00679-0
(2004)Doi:10.1016/S0021-9517(02)00011-8
(2003)Doi:10.1021/ja01550a024
(1958)Doi:10.1021/jo01075a627
(1960)Doi:10.1007/s11243-020-00415-7
(2020)Doi:10.1021/acs.orglett.9b02021
(2019)
