Hydroxylation of Deoxyguanosine at the C-8 Position in the Thiosulfate-Hydrogen Peroxide Reaction System. Evidence of Hydroxyl Radical Generation in the System

Article abstract of DOI:10.1246/cl.1994.993

The thiosulfate-hydrogen peroxide reaction system generates thiosulfate radical anion and hydroxyl radical.When 2'-deoxyguanosine (dG) was included in the system, it was hydroxylated at the C-8 position, and the hydroxylation was markedly enhanced by addition of a trace amount of iron ion.