Highly stereoselective addition of tin enolate to α-chloro cyclic ketone derivatives catalyzed by Ph4SbBr

Article abstract of DOI:10.1016/S0040-4039(00)78455-3

Tetraphenylstibonium bromide was shown to be an effective catalyst for the stereoselective nucleophilic addition of tin enolates 2 to α-chloro cyclic ketone derivatives 1, furnishing chlorohydrins 3 bearing chloro- and hydroxyl groups in cis-conformation