Utility of 6-amino-2-thiouracil as a precursor for the synthesis of pyrido[2,3-d]pyrimidines and their in vitro and in vivo biological evaluation

Article abstract of DOI:10.3797/scipharm.2007.75.9

The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azamethine derivatives 3a,b. The formed azamethines underwent [4+2] cycloaddition with enaminones 4a-c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a-f an

Full text of DOI:10.3797/scipharm.2007.75.9

Scientia Pharmaceutica (Sci. Pharm.) 75, 9-28 (2007)
Österreichische Apotheker-Verlagsgesellschaft m. b. H., Wien, Printed in Austria
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S\ULGR>ꢀꢃꢂꢁG@S\ULPLGLQꢁꢉꢁRQHꢃ ꢌGꢍ EURZQFU\VWDOVꢃ \LHOGꢑꢈꢂꢃꢏJꢉꢒꢏꢓꢋꢌPSꢑꢃꢃꢒ &ꢌ
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5 ꢉ.%Uꢁ FP ꢋꢑ ꢈꢈꢈꢊ ꢉ1+ꢋꢁ ꢀꢄꢆꢊ ꢉ&2ꢋꢁ ꢀꢄꢈꢀ ꢉ&2ꢋꢌ +ꢅ105 ꢉ'062ꢅG ꢋꢑ į ꢉSSPꢋ
ꢄ
ꢈꢂꢒꢏ ꢉVꢁ ꢈ +ꢁ 2&+ ꢋꢁ ꢄꢂꢎꢄ ꢉGꢁ ꢃ+ꢁ DURPDWLF SURWRQVꢁ - ꢎꢂꢏ +]ꢋꢁ ꢄꢂꢍꢄ ꢉGꢁ ꢃ+ꢁ
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DURPDWLF SURWRQVꢁ - ꢎꢂꢏꢋꢁ ꢎꢂꢊꢈꢅꢎꢂꢀꢈ ꢉPꢁ ꢀ+ꢁ IXUDQ SURWRQꢋꢁ ꢎꢂꢈꢏ ꢉVꢁ ꢀ+ꢁ +ꢅꢄꢋꢁ ꢎꢂꢄꢎ

Utility of 6-Amino-2-thiouracil as a Precursor for the Synthesis of Pyrido...
13
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1
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FP ꢋꢑꢈꢈꢍꢍꢉ1+ꢋꢁꢀꢄꢆꢈꢉ&2ꢋꢁꢀꢄꢈꢊꢉ&2ꢋꢌ +ꢅ105ꢉ'062ꢅG ꢋꢑį ꢉSSPꢋ ꢄꢂꢎꢊꢅꢎꢂꢃꢏ
ꢄ
ꢉPꢁ ꢏ+ꢁ DURPDWLF SURWRQVꢋꢁ ꢎꢂꢈꢊ ꢉVꢁ ꢀ+ꢁ +ꢅꢄꢋꢁ ꢎꢂꢏꢆꢅꢒꢂꢊꢃ ꢉPꢁ ꢄ+ꢁ QDSKWK\O SURWRQVꢋꢁ
ꢒꢂꢏꢊꢉVꢁꢀ+ꢁQDSKWK\O SURWRQꢋꢁꢀꢀꢂꢒꢏꢉVꢁꢀ+ꢁ1+ꢋꢁꢀꢃꢂꢀꢊꢉVꢁꢀ+ꢁ1+ꢋꢌ06ꢉPꢐ]ꢋ ꢆꢊꢍ
ꢇ
ꢉ0 ꢁ ꢆꢈꢓꢋꢂ $QDOꢂ &DOFGꢂ )RU & + 1 2 6ꢑ & ꢎꢊꢂꢆꢊꢓꢁ + ꢈꢂꢄꢍꢓꢁ 1 ꢀꢊꢂꢃꢄꢓꢁ 6
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ꢄ
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14
Nadia Ragab Mohammed et al.:
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Utility of 6-Amino-2-thiouracil as a Precursor for the Synthesis of Pyrido...
15
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