Synthesis of atamestane (SH 489): An aromatase inhibitor

Article abstract of DOI:10.1080/00397919508015502

Atamestane (SH 489) was synthesized from 17β-Acetyoxy-1α-methyl-5α-androstan-3-one. Thus dibromination followed by dehydrobromination of the A-ring have dienone (5) in good yield, which was hydrolyzed and oxidized to give the title compound in 60% overall yield.

Full text of DOI:10.1080/00397919508015502

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Synthesis of Atamestane (SH
4
89): An Aromatase Inhibitor
a a
Mettilda Lourdusamy , Fernand Labrie & Shankar
a
M. Singh
a
Medicinal Chemistry Division , Laboratory of
Molecular Endocrinology, CHUL Research Center ,
Québec City, Québec, GIV 4G2, Canada
Published online: 23 Sep 2006.
To cite this article: Mettilda Lourdusamy , Fernand Labrie & Shankar M. Singh (1995)
Synthesis of Atamestane (SH 489): An Aromatase Inhibitor, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
25:22, 3655-3662, DOI: 10.1080/00397919508015502
To link to this article: http://dx.doi.org/10.1080/00397919508015502
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