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Name	L-Cystine	EINECS	200-296-3
CAS No.	56-89-3	Density	1.571 g/cm³
PSA	177.24000	LogP	0.59220
Solubility	0.112 g/L (25 °C) in water	Melting Point	>240 °C (dec.)(lit.)
Formula	C₆H₁₂N₂O₄S₂	Boiling Point	468.2 °C at 760 mmHg
Molecular Weight	240.304	Flash Point	237 °C
Transport Information	N/A	Appearance	White crystalline powder
Safety	26-36-24/25	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	L-Cystine;1-cystine;L-CYSTINE;l-cystin;h-(cys);(H-Cys-OH)2;(R,R)-3,3'-Dithiobis(2-aminopropionicacid);Cystin;[3H]-Cystine;(CYS)2;.β.,.β.'-Diamino-.β.,.β.'-dicarboxydiethyl disulfide;(R,R)-cystine;Nephrin;Dicysteine;L-CYTISINE;查看更多英文别名收起	Article Data	312

L-Cystine Synthetic route

: 52-90-4
L-Cysteine

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With 3-bromo-2-(1-hydroxycyclohexyl)[1,2]selenazolo[2,3-a]pyridinium chloride; dihydrogen peroxide In methanol; water at 20℃; for 0.166667h;	100%
With dihydrogen peroxide; sodium iodide In water at 25℃; for 1h; Cooling with ice;	100%
With bis(4-methoxyphenyl)telluride; rose bengal In water; isopropyl alcohol at 0℃; for 0.833333h; Irradiation;	99%

: 52-90-4
L-Cysteine

: 73243-09-1
(R)-2-Amino-3-(4-methoxy-phenylmethanesulfinyl)-propionic acid

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With dimethylsulfide; trifluorormethanesulfonic acid In trifluoroacetic acid at 0℃; for 1h;	100%

: 84888-38-0
(R)-9H-fluorenyl-9-methyl-L-cysteine

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With piperidine In N,N-dimethyl-formamide for 2h;	100%

: 134469-02-6, 51209-75-7
S-nitroso-L-cysteine

A: 56-89-3
L-cystine

B NO: NO

Conditions

Conditions	Yield
With copper(II) ion In water at 25℃; Rate constant; var. conc. of Cu2+;	A 100% B n/a

: 2481-10-9
(R)-S-tert-butylcysteine

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With Methyltrichlorosilane; 1,1'-sulfinylbisbenzene at 4℃; for 0.166667h;	99%

: 52-90-4
L-Cysteine

: 75893-05-9
H-Cys(Acm)(O)-OH

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With dimethylsulfide In trifluoroacetic acid at 0℃; for 1h;	97.9%

Reaxys ID: 11465027: Reaxys ID: 11465027

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With sodium hydroxide In water at 20 - 60℃; for 2h; pH=~ 4.0;	97%
With ammonia In water at 20 - 60℃; for 0.666667 - 2h; pH=~ 3.0;	97%
With ammonia In water at 20 - 80℃; for 2h; pH=~ 2.3 - ~ 3.0;	95%

: 52-90-4
L-Cysteine

: 134861-13-5
N-(benzoylsulfide)benzamide

A: 56-89-3
L-cystine

B: 55-21-0
benzamide

C: D-N-benzoylcysteine

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer at 20℃; pH=7.4;	A 95% B 96% C 80%

: 2544-31-2
S-(4-methoxybenzyl)-L-cysteine

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With Methyltrichlorosilane; 1,1'-sulfinylbisbenzene at 4℃; for 0.166667h;	95%
With methoxybenzene; thallium(III) trifluoroacetate In trifluoroacetic acid at 0℃; for 1h;	86.7%
With methoxybenzene; thallium(III) trifluoroacetate In trifluoroacetic acid at 0℃; for 1h; Product distribution; cleavage various S-protecting groups of cystein;	86.7%

: 19647-70-2
S-acetamidomethyl-L-cysteine

: 56-89-3
L-cystine

Conditions

Conditions	Yield
With Methyltrichlorosilane; 1,1'-sulfinylbisbenzene at 4℃; for 0.5h;	93%
With Methyltrichlorosilane; 1,1'-sulfinylbisbenzene at 4℃; for 0.5h; Product distribution; other S-protected cysteines;	93%

L-Cystine Specification

1. Introduction of L-Cystine

L-Cystine, with the IUPAC Name of (2R)-2-amino-3-[(2R)-2-amino-3-hydroxy-3-oxopropyl]disulfanylpropanoic acid, is one kind of white crystalline powder. Stability: For being stable in the normal condition, it is incompatible with strong oxidizing agents, and this chemical belongs to the Product Categories which include Food and Feed Additive; Amino Acids; Amino Acid Derivatives; Cysteine [Cys, C]; Nutritional Supplements; L-Amino Acids; Amino Acids.

2. Properties of L-Cystine

L-Cystine has the following property datas: (1)Melting Point: >240 °C (dec.)(lit.); (2)Surface Tension: 88.2 dyne/cm ; (3)Density: 1.571 g/cm3 ; (4)Flash Point: 237 °C ; (5)Enthalpy of Vaporization: 80.02 kJ/mol ; (6)Boiling Point: 468.2 °C at 760 mmHg ; (7)Vapour Pressure: 4.62E-10 mmHg at 25°C ; (8)Water Solubility: 0.112 g/L (25 °C).

3. Structure Descriptors of L-Cystine

You could convert the following datas into the molecular structure:
InChI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
InChIKey: InChIKey=LEVWYRKDKASIDU-IMJSIDKUSA-N
Smiles: C([C@@H](C(O)=O)N)SSC[C@@H](C(O)=O)N

4. Toxicity of L-Cystine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 961mg/kg (961mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974.
rat	LDLo	oral	25gm/kg (25000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 199, 1978.

5. Safety Information of L-Cystine

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
RIDADR: 2811
WGK Germany: 3
RTECS: HA2690000
Hazard Note: Irritant
PackingGroup: III
HS Code: 29309014

6. Use of L-Cystine

Cystine (CAS NO.56-89-3) can be mainly used for various disease alopecia. Also it can be used for dysentery, typhoid, influenza and other acute infectious diseases, asthma, neuralgia, eczema and various diseases, such as poisoning, and protein structure to maintain the role. It is also used as a food flavoring agent.

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