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Polymyxin B sulfate

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  • Name Polymyxin B sulfate
  • EINECS215-774-7
  • CAS No. 1405-20-5
  • DensityN/A
  • PSA573.64000
  • LogP2.54990
  • Solubilitywater: 50 mg/mL
  • Melting Point217-220°C (dec.)
  • FormulaC56H98N16O13.H2SO4
  • Boiling Point1651ºC at 760 mmHg
  • Molecular Weight1301.56
  • Flash Point952.3ºC
  • Transport InformationN/A
  • AppearanceWhite crystalline powder
  • Safety22-24/25
  • Risk Codes22
  • Molecular Structure
    Molecular Structure of 1405-20-5 (Polymyxin B sulfate)
  • Hazard SymbolsHarmfulXn
  • SynonymsHarmfulXn

Polymyxin B sulfate Chemical Properties

Molecular Formula: C56H100N16O17S
Molecular Weight: 1301.56
EINECS: 215-774-7 
Flash Point: 952.3 °C
Enthalpy of Vaporization: 272.45 kJ/mol
Boiling Point: 1651 °C at 760 mmHg
Storage tempreture: 2-8 °C
Solubility: H2O: 50 mg/mL
Form: Powder
Structure of Polymyxin B sulfate (CAS NO.1405-20-5):

Product Category of Polymyxin B sulfate (CAS NO.1405-20-5): Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Antibiotics;Reagents and Supplements

Polymyxin B sulfate Uses

 Polymyxin B sulfate (CAS NO.1405-20-5) is used for resistant gram negative infections as an antibiotic. In addition to its antibiotic function, it has been used to clear endotoxin contamination in reagents

Polymyxin B sulfate Toxicity Data With Reference

1.    

dnd-esc 50 mg/L

    MUREAV    Mutation Research. 89 (1981),95.
2.    

orl-mus LD50:790 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
3.    

ipr-mus LD50:20,500 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
4.    

scu-mus LD50:59,500 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
5.    

ivn-mus LD50:5400 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
6.    

ivn-dog LDLo:8 mg/kg

    INURAQ    Investigative Urology. 6 (1969),505.
7.    

ice-dog LDLo:320 µg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 23 (1964),552.

Polymyxin B sulfate Safety Profile

Poison by intravenous, subcutaneous, intraperitoneal and intracerebral routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also POLYMYXIN B.
Hazard Codes: HarmfulXn
Risk Statements: 22 
R22:Harmful if swallowed.
Safety Statements: 22-24/25 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes.

Polymyxin B sulfate Specification

 Polymyxin B sulfate , its cas register number is 1405-20-5. It also can be called N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid .

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