BroMo-tert-butyl Alcohol

Base Information

• Chemical Name: BroMo-tert-butyl Alcohol
• CAS No.: 38254-49-8
• Molecular Formula: C4H9BrO
• Molecular Weight: 153.019
• Mol file: 38254-49-8.mol

Synonyms:Bromo-tert-butyl Alcohol;

Chemical Property of BroMo-tert-butyl Alcohol

Chemical Property:

• Boiling Point: 49.5 °C(Press: 16 Torr)
• PKA: 13.95±0.29(Predicted)
• PSA: 20.23000
• Density: 1.437 g/cm3(Temp: 25 °C)
• LogP: 1.15220
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

≥99.0% ^*data from raw suppliers

Bromo-tert-butylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Bromo-tert-butyl Alcohol, is an organic building block that can be used in the variety of chemical synthesis. It is used in the synthesis of Monohalogeno-t-butyloxycarbonylamino Acids.

Technology Process of BroMo-tert-butyl Alcohol

There total 3 articles about BroMo-tert-butyl Alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

t-butyl bromide (507-19-7) → 1,2-dibromo-2-methyl-propane (594-34-3) + 1-bromo-2-methylpropane-2-ol (38254-49-8) + isobutene (115-11-7,15220-85-6) + tert-butyl alcohol (75-65-0)

Guidance literature:

With dimethylsulfoxide-d6; at 60 ℃; Rate constant; other solvents;

DOI:10.1246/bcsj.67.824

Reference yield:

isobutene (115-11-7,15220-85-6) → 2-methyl-3-bromo-1-propene (1458-98-6) + 1,2-dibromo-2-methyl-propane (594-34-3) + 1-bromo-2-methylpropane-2-ol (38254-49-8)

Guidance literature:

With hydrogen bromide; oxygen; sodium nitrite; In water; at 40 ℃; under 760.051 Torr; Ionic liquid;

DOI:10.1007/s10562-014-1298-1

Reference yield:

2-methyl-1,2-epoxypropane (558-30-5) + diethyl ether (60-29-7,927820-24-4) → 2-methyl-3-pentanol (565-67-3) + 1-bromo-2-methylpropane-2-ol (38254-49-8) + isobutyraldehyde (78-84-2)

Guidance literature:

DOI:10.1021/jo01152a014

upstream raw materials:

t-butyl bromide

2-methyl-1,2-epoxypropane

diethyl ether

isobutene

Downstream raw materials:

isobutyraldehyde

1-{4-[(1R,3S)-6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-2-methyl-propan-2-ol

2-Methyl-1,2-propanediol

3-hydroxy-3-methylbutyronitrile

Refernces

• 1、 Kuznetsova, Lidia I.,Kuznetsova, Nina I.,Zudin, Vladimir N.,Utkin, Viktor A.,Trebushat, Dmitry V.,Fedotov, Martin A.,Larina, Tatyana V.. "Oxidative bromination of alkenes mediated with nitrite in ionic liquids". . p. 1499 - 1506,8. Retrieved 2014/11/08.