Glycine

Base Information

• Chemical Name: Glycine
• CAS No.: 18875-39-3
• Deprecated CAS: 52955-63-2,57678-19-0,87867-94-5,848646-45-7,1119449-36-3,1173020-11-5,1196157-78-4,1153953-88-8,1119449-36-3,1153953-88-8,1196157-78-4,57678-19-0,848646-45-7,87867-94-5
• Molecular Weight: 75.06
• European Community (EC) Number: 200-272-2,654-407-9
• NSC Number: 760120,25936
• UNII: TE7660XO1C
• DSSTox Substance ID: DTXSID9020667
• Nikkaji Number: J1.163K
• Wikipedia: Glycine,Glycin
• Wikidata: Q620730,Q27115084,Q105103935
• NCI Thesaurus Code: C524
• RXCUI: 4919
• Pharos Ligand ID: YXX31QZ3CNMJ
• Metabolomics Workbench ID: 37085
• ChEMBL ID: CHEMBL773
• Mol file: 18875-39-3.mol

Synonyms:Acid, Aminoacetic;Aminoacetic Acid;Calcium Salt Glycine;Cobalt Salt Glycine;Copper Salt Glycine;Glycine;Glycine Carbonate (1:1), Monosodium Salt;Glycine Carbonate (2:1), Monolithium Salt;Glycine Carbonate (2:1), Monopotassium Salt;Glycine Carbonate (2:1), Monosodium Salt;Glycine Hydrochloride;Glycine Hydrochloride (2:1);Glycine Phosphate;Glycine Phosphate (1:1);Glycine Sulfate (3:1);Glycine, Calcium Salt;Glycine, Calcium Salt (2:1);Glycine, Cobalt Salt;Glycine, Copper Salt;Glycine, Monoammonium Salt;Glycine, Monopotassium Salt;Glycine, Monosodium Salt;Glycine, Sodium Hydrogen Carbonate;Hydrochloride, Glycine;Monoammonium Salt Glycine;Monopotassium Salt Glycine;Monosodium Salt Glycine;Phosphate, Glycine;Salt Glycine, Monoammonium;Salt Glycine, Monopotassium;Salt Glycine, Monosodium

Chemical Property of Glycine

Chemical Property:

• XLogP3: -3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 75.032028402
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(C(=O)O)N
• Recent ClinicalTrials: Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19
• Recent EU Clinical Trials: A randomised, double-blind study evaluating the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact(R) in premature very low birth weight (VLBW) infants
• Recent NIPH Clinical Trials: Effects of amino acids on nonalcoholic fatty liver disease

Technology Process of Glycine

There total 833 articles about Glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.8%

pyrrolidine (123-75-1) + formic acid (64-18-6) → pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) + glycine (56-40-6,18875-39-3,25718-94-9) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7)

Guidance literature:

In water; at 10 - 20 ℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);

Reference yield: 0.4%

pyrrolidine (123-75-1) + sodium formate (141-53-7) → pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) + glycine (56-40-6,18875-39-3,25718-94-9) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7)

Guidance literature:

In water; at 10 - 20 ℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);

Reference yield:

N-(4-methoxybenzoyl)glycine (13214-64-7) → 4-methoxybenzoic acid (100-09-4) + glycine (56-40-6,18875-39-3,25718-94-9)

Guidance literature:

With water; N-benzoyl-L-alanine amidohydrolase; Product distribution; Kinetics; substrate specifity of N-benzoyl-L-alanine amidohydrolase;

upstream raw materials:

Hippuric Acid

diazoacetic acid ethyl ester

DL-threonine

methanol

Downstream raw materials:

N^α-(2,4-dinitro-phenyl)-L-histidine

4-furfurylidene-1-phenyl-2-thioxoimidazolidin-5-one

(5Z)-5-(furan-2-ylmethylene)-2-thioxoimidazolidin-4-one

(Z)-4-((carboxymethyl)amino)-4-oxobut-2-enoic acid