2-Methoxy-1,3,2-dioxaphospholane

Base Information

• Chemical Name: 2-Methoxy-1,3,2-dioxaphospholane
• CAS No.: 3741-36-4
• Molecular Formula: C3H7 O3 P
• Molecular Weight: 122.061
• Hs Code.: 2934999090
• European Community (EC) Number: 223-130-1
• NSC Number: 171170
• DSSTox Substance ID: DTXSID40190853
• Nikkaji Number: J50.404A
• Wikidata: Q83063303
• Mol file: 3741-36-4.mol

Synonyms:2-Methoxy-1,3,2-dioxaphospholane;Methoxyphosphorane;Cyclic ethylene methyl phosphite;Methyl ethylene phosphite;3741-36-4;EINECS 223-130-1;O,O-Bis(ethylene)-O-methyl phosphite;Ethylene diethylphosphoramidite;Ethylene diethylamido phosphite;PHOSPHOROUS ACID, CYCLIC ETHYLENE METHYL ESTER;2-Methoxy-1,2,3-dioxaphospholane;Ethylene methyl phosphite, (C2H4O2)(MeO)P;1,3,2-Dioxaphospholane, 2-methoxy-;NSC 171170;BRN 0605525;2-Methoxy-1,3,2-dioxafosfolan [Czech];2-Methoxy-1,3,2-dioxafosfolan;1,3,2-Dioxaphospholane,2-methoxy-;2-METHOXY-[1,3,2]-DIOXAPHOSPHOLANE;WLN: T5OPOTJ BO1;O(C)P1OCCO1;SCHEMBL1108996;2-Methoxy-1,2-dioxaphospholane;2-Methoxy-1,3-dioxaphospholane;DTXSID40190853;1,2-Dioxaphospholane, 2-methoxy-;NSC171170;AKOS006277362;NSC-171170;LS-109003

Chemical Property of 2-Methoxy-1,3,2-dioxaphospholane

Chemical Property:

• Vapor Pressure: 93.3mmHg at 25°C
• Boiling Point: 80.8°Cat760mmHg
• Flash Point: °C
• PSA: 41.28000
• Density: g/cm³
• LogP: 0.90650
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 122.01328108
• Heavy Atom Count: 7
• Complexity: 52.1

Purity/Quality:

99% ^*data from raw suppliers

2-METHOXY-1,3,2-DIOXAPHOSPHOLANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COP1OCCO1

Technology Process of 2-Methoxy-1,3,2-dioxaphospholane

There total 17 articles about 2-Methoxy-1,3,2-dioxaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 2-chloro-1,3,2-dioxaphospholan (822-39-9) → methoxy-2 dioxaphospholane-1,3,2 (3741-36-4)

Guidance literature:

methanol; In dichloromethane; at 20 ℃; for 0.5h;

2-chloro-1,3,2-dioxaphospholan; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

methanol (67-56-1) + [1,3,2]dioxaphospholan-2-yl-dimethyl-amine (7114-39-8) → dimethyl amine (124-40-3) + methoxy-2 dioxaphospholane-1,3,2 (3741-36-4)

Guidance literature:

N,N-dimethylammonium chloride; In chloroform-d1; at 40 ℃;

Reference yield:

ethylene glycol (107-21-1) + phosphorous acid trimethyl ester (121-45-9) → methoxy-2 dioxaphospholane-1,3,2 (3741-36-4)

Guidance literature:

With sodium;

DOI:10.1021/jo00969a024

upstream raw materials:

methyl dichlorophosphite

ethylene glycol

diethyl ether

N,N-diethylaniline

Downstream raw materials:

2,4-diisopropylidene-5-methoxy-1,3,6,9-tetraoxa-5λ⁵-phospha-spiro[4.4]nonane

5,7-Dimethoxy-6,12-di-p-tolyl-1,4,8,11-tetraoxa-6,12-diaza-5λ⁵,7λ⁵-diphospha-dispiro[4.1.4.1]dodecane

2,3-Diphenyl-5-methoxy-1,4,6,9-tetraoxa-5-phospha-spiro[4.4]-Δ²-nonen

5,7-Dimethoxy-6,12-diphenyl-1,4,8,11-tetraoxa-6,12-diaza-5λ⁵,7λ⁵-diphospha-dispiro[4.1.4.1]dodecane