1-Chloro-1-fluoroethane

Base Information

• Chemical Name: 1-Chloro-1-fluoroethane
• CAS No.: 1615-75-4
• Molecular Formula: C2H4 Cl F
• Molecular Weight: 82.5052
• Hs Code.: 2903791090
• DSSTox Substance ID: DTXSID60869534
• Nikkaji Number: J28.320G
• Mol file: 1615-75-4.mol

Synonyms:1-Chloro-1-fluoroethane;1615-75-4;Chlorofluoroethane;ETHANE, 1-CHLORO-1-FLUORO-;Freon 151;1-Chlorofluoroethane;Ethane, chlorofluoro-;Monochloromonofluoroethane;110587-14-9;BRN 1730840;1-chloro-fluoroethane;1-chloranyl-1-fluoranyl-ethane;DTXSID60869534;MFCD00221779;AKOS006229374;LS-65243;FT-0607579;A810275;Ethyl2-amino-5-(4-methoxy-phenyl)-4-methyl-thiophene-3-carboxylate

Chemical Property of 1-Chloro-1-fluoroethane

Chemical Property:

• Refractive Index: 1.3879 (estimate)
• Boiling Point: 12.6°Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: 1.047g/cm³
• LogP: 1.54070
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 81.9985560
• Heavy Atom Count: 4
• Complexity: 15.5

Purity/Quality:

97% ^*data from raw suppliers

1-Chloro-1-fluoroethane 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 10-23/24/25-59
• Safety Statements: 16-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(F)Cl

Technology Process of 1-Chloro-1-fluoroethane

There total 15 articles about 1-Chloro-1-fluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

HCFC-141b (1717-00-6) → 1-fluoroethane (353-36-6) + chloroethane (75-00-3) + 1-chloro-1-fluoroethane (1615-75-4)

Guidance literature:

With hydrogen; platinum on activated charcoal; at 200 ℃;

DOI:10.1016/0022-1139(95)03347-5

Reference yield:

1,1-dichloroethane (75-34-3) → 1,1-difluoroethane (75-37-6) + ethene (74-85-1) + 1-chloro-1-fluoroethane (1615-75-4) + 1-fluoroethylene (75-02-5,24981-14-4) + chloroethylene (75-01-4,9002-86-2) + 1,1-Dichloroethylene (75-35-4,9002-85-1)

Guidance literature:

With hydrogen fluoride; at 290 ℃;

Reference yield:

1,1-dichloroethane (75-34-3) → 1,1-difluoroethane (75-37-6) + ethene (74-85-1) + 1-chloro-1-fluoroethane (1615-75-4) + 1-fluoroethylene (75-02-5,24981-14-4) + chloroethylene (75-01-4,9002-86-2) + 1-chloro-1-fluoroethane (2317-91-1) + 1,1-Dichloroethylene (75-35-4,9002-85-1)

Guidance literature:

With hydrogen fluoride; at 200 - 250 ℃;

upstream raw materials:

1,1-dichloroethane

chloroethylene

carbonofluoridic acid 2-chloro-ethyl ester

1-bromo-1-chloroethane

Downstream raw materials:

1-fluoroethylene

chloroethylene

Refernces

Synthesis of arylethyl (E)-styrylsulfones and arylsulfones by one-pot DIBAL-H/NaH-mediated reaction of β-ketosulfones

10.1055/s-0033-1339117

The research focuses on the development of a one-pot synthetic route for the preparation of arylethyl (E)-styrylsulfones and arylsulfones using DIBAL-H/NaH-mediated reaction of β-ketosulfones. The study explores the reduction of α-benzyl-β-arylketosulfones and the subsequent retroaldol/aldol reaction of the resulting intermediates under mild conditions. The reaction mechanism involving the formation of intermediates through reduction, retroaldol bond rotation/proton exchange, and aldol condensation is discussed. The experiments utilized various reductants, bases, and starting materials, such as α-benzyl-α-benzoylsulfone, to optimize the reaction conditions for the highest yields of the desired products. The analyses used to characterize the products included TLC, 1H NMR, and single-crystal X-ray crystallography, with yields and purities of the products being determined accordingly.