1,1,1,2-Tetrafluoroethane

Base Information

• Chemical Name: 1,1,1,2-Tetrafluoroethane
• CAS No.: 811-97-2
• Molecular Formula: C2H2F4
• Molecular Weight: 102.031
• Hs Code.: 29033990
• European Community (EC) Number: 212-377-0
• ICSC Number: 1281
• UN Number: 3159
• UNII: DH9E53K1Y8
• DSSTox Substance ID: DTXSID1021324
• Nikkaji Number: J7.107B
• Wikipedia: 1,1,1,2-Tetrafluoroethane
• Wikidata: Q423029
• NCI Thesaurus Code: C77482
• RXCUI: 1311560
• Metabolomics Workbench ID: 153982
• ChEMBL ID: CHEMBL2104432
• Mol file: 811-97-2.mol

Synonyms:1,1,1,2-tetrafluoroethane;FC-134a;GR 106642X;HFA 134a;HFA-134a;HFC 134a;HFC-134a;HFC134a;hydrofluoroalkane-134a;norflurane;R 134a;R-134a

Chemical Property of 1,1,1,2-Tetrafluoroethane

Chemical Property:

• Appearance/Colour: colourless gas or cryogenic liquid
• Vapor Pressure: 6630mmHg at 25°C
• Melting Point: -101 °C
• Refractive Index: 1.225
• Boiling Point: -26.2 °C
• PSA: 0.00000
• Density: 1.223 g/cm³
• LogP: 1.51820
• Solubility.: Soluble in ethanol (95%), ether, and 1 in 1294 parts of water at 20℃.
• Water Solubility.: 1g/L at 25℃
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 102.00926271
• Heavy Atom Count: 6
• Complexity: 35.3
• Transport DOT Label: Non-Flammable Gas

Purity/Quality:

99% ^*data from raw suppliers

1,1,1,2-Tetrafluoroethane 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 23-38

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Chlorofluorocarbons
• Canonical SMILES: C(C(F)(F)F)F
• Inhalation Risk: A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
• Effects of Short Term Exposure: Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system and cardiovascular system. This may result in cardiac disorders.
• Uses: It can be used as the refrigerant in fridge and refrigerator and automotive air conditioning as well as the aerosol propellant of medicine and cosmetics. It can be used as animal-used antibiotic with stable quality. It is not easy to produce drug resistance and cross-resistance and has a high antibacterial activity in vivo. It is mainly applied to the treatment of E. coli disease in livestock and poultry, cholera, dysentery, chronic respiratory infections and other diseases. Refrigerant, propellant for pharmaceuticals; blowing agent for foams.

Technology Process of 1,1,1,2-Tetrafluoroethane

There total 77 articles about 1,1,1,2-Tetrafluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

1,1-dichlorotetrafluoroethane (374-07-2) → 2,2,2-trifluoroethanol (420-46-2) + 1,1,1,2-tetrafluoroethane (811-97-2) + 1,1,1,2-tetrafluoro-2-chloroethane (2837-89-0)

Guidance literature:

With hydrogen; palladium/alumina; at 140 ℃; Product distribution; Mechanism; var. temp.; other catalysts;

DOI:10.1006/jcat.1996.0394

Reference yield: 70.0%

1,1,1-trifluoro-2-chloroethane (75-88-7) + 2,2,2-trifluoroethanol (75-89-8) → 1,1,1,2-tetrafluoroethane (811-97-2) + 1-Chloro-2,2-difluoroethene (359-10-4) + 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane (333-36-8)

Guidance literature:

With potassium hydroxide; at 250 ℃; for 13h; under 77520 Torr;

DOI:10.1016/S0022-1139(01)00469-9

Reference yield:

chloroform (67-66-3,8013-54-5) → pentaerythrityl tetrachloride (3228-99-7) + 1,1,1,2-tetrafluoroethane (811-97-2) + 1,1,1-trifluoro-2-chloroethane (75-88-7) + 1,2-dichloro-1,1-difluoroethane (1649-08-7) + 1,2,3-trichloro-2-chloromethyl-propane (18963-00-3) + 1,1,2,2-tetrachloroethane (79-34-5)

Guidance literature:

With fluorinated gallium(III) oxide; Product distribution; Ambient temperature; further reagent: fluorinated indium(III) oxide;

DOI:10.1039/a802365d

upstream raw materials:

2,2,2-Trifluoroethyl p-toluenesulfonate

glycolic Acid

Vinylidene fluoride

Fluoroacetic acid

Downstream raw materials:

Carbonyl fluoride

formyl fluoride

trifluoroacetyl fluoride

trifluoromethanol

Refernces

• 1、 Ogata, Teruhiko,Miki, Yasuhiro. "MICROWAVE SPECTRUM, BARRIER TO INTERNAL ROTATION, STRUCTURE, AND DIPOLE MOMENT OF 1,1,1,2-TETRAFLUOROETHANE". . p. 49 - 56. Retrieved 1986.
• 2、 Madhusudana Rao, Jampani,Shanthan Rao,Vijayakumar,Venkata Rao,Narsaiah,Narayan Reddy,Leela Krishna,Srinivas,Radhakrishnan,Patil. "Effect of acid strength of co-precipitated chromia/alumina catalyst on the conversion and selectivity in the fluorination of 2-chloro-1,1,1-trifluoroethane to 1,1,1,2-tetrafluoroethane". . p. 177 - 180. Retrieved 1999.
• 3、 Aigbirhio, Franklin I.,Pike, Victor W.,Waters, Stephen L.,Tanner, Richard J. N.. "Efficient regioselective labelling of the CFC alternative 1,1,1,2-tetrafluoroethane (HFC-134a) with fluorine-18". . p. 279 - 288. Retrieved 1995.
• 4、 -. "CATALYST AND PROCESS USING THE CATALYST FOR MANUFACTURING FLUORINATED HYDROCARBONS". Page/Page column 10; 11; 12; 17. . Retrieved 2018/03/28.
• 5、 -. "Device and method for preparing 1,1,1,2-tetrafluoroethane". Paragraph 0023-0024. . Retrieved 2017/06/20.