4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL

Base Information

• Chemical Name: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL
• CAS No.: 103905-49-3
• Molecular Formula: C10H14 F N O2
• Molecular Weight: 199.225
• Mol file: 103905-49-3.mol

Synonyms:4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL

Chemical Property of 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL

Chemical Property:

• PSA: 32.70000
• LogP: 1.60150
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

4-(Dimethylaminomethyl)-6-fluoro-2-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL

There total 4 articles about 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-fluoro-6-methoxyphenol (73943-41-6) + dimethyl amine (124-40-3) → 5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene (103905-49-3)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1021/jo00371a031

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-fluoro-6-methoxyphenol (73943-41-6) + methylamine (74-89-5) → 5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene (103905-49-3)

Guidance literature:

In ethanol; water; for 2h; Reflux;

Reference yield: 95.0%

2-fluoro-6-methoxyphenol (73943-41-6) + dimethyl amine (124-40-3) → 5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene (103905-49-3)

Guidance literature:

In ethanol; water; for 2h; Heating;

DOI:10.1021/jm00384a015

upstream raw materials:

formaldehyd

2-fluoro-6-methoxyphenol

dimethyl amine

methylamine

Downstream raw materials:

3-fluoro-4-hydroxy-5-methoxybenzaldehyde

1-fluoro-2-hydroxy-3-methoxy-5-methylbenzene

3,4-dimethoxy-5-fluorophenethylamine

3-fluoro-4,5-dimethoxybenzaldehyde

Refernces

• 1、 Alen, Jo,Schade, Markus,Wagener, Markus,Christian, Frank,Nordhoff, Sonja,Merla, Beatrix,Dunkern, Torsten R.,Bahrenberg, Gregor,Ratcliffe, Paul. "Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors". supporting information. p. 6391 - 6397. Retrieved 2019/07/08.
• 2、 Maresh, Justin J.,Ralko, Arthur A.,Speltz, Tom E.,Burke, James L.,Murphy, Casey M.,Gaskell, Zachary,Girel, Joann K.,Terranova, Erin,Richtscheidt, Conrad,Krzeszowiec, Mark. "Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues". supporting information. p. 2891 - 2894. Retrieved 2015/02/02.