Ethanone, 1-[2-(dimethylamino)phenyl]- (9CI)

Base Information

• Chemical Name: Ethanone, 1-[2-(dimethylamino)phenyl]- (9CI)
• CAS No.: 10336-55-7
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2922399090
• Mol file: 10336-55-7.mol

Synonyms:Acetophenone,2'-(dimethylamino)- (6CI,7CI,8CI); 2'-(Dimethylamino)acetophenone;o-(Dimethylamino)acetophenone

Chemical Property of Ethanone, 1-[2-(dimethylamino)phenyl]- (9CI)

Chemical Property:

• Boiling Point: 91-94 °C(Press: 1.5 Torr)
• PKA: 3.55±0.18(Predicted)
• PSA: 20.31000
• Density: 1.026±0.06 g/cm3(Predicted)
• LogP: 1.95520

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Dimethylamino-phenyl)-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[2-(dimethylamino)phenyl]- (9CI)

There total 5 articles about Ethanone, 1-[2-(dimethylamino)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2'-Fluoroacetophenone (445-27-2) + dimethyl amine (124-40-3) → 2-N,N-dimethylaminoacetophenone (10336-55-7)

Guidance literature:

With potassium carbonate; In water; at 130 ℃; for 0.583333h; Microwave irradiation;

DOI:10.3998/ark.5550190.p009.692

Reference yield:

2-aminoacetophenone (551-93-9) + methyl iodide (74-88-4) → 2-N,N-dimethylaminoacetophenone (10336-55-7)

Guidance literature:

With methanol; at 100 ℃; im Rohr;

Reference yield:

acetic anhydride (108-24-7) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → 2-N,N-dimethylaminoacetophenone (10336-55-7) + 4'-dimethylaminoacetophenone (2124-31-4)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In acetonitrile; for 6h; Time; Overall yield = 96 %; Inert atmosphere; Microwave irradiation; Heating; Green chemistry;

DOI:10.1039/c3gc40720a

upstream raw materials:

methyl magnesium iodide

2-N,N-dimethylaminobezonitrile

N,N-dimethylanthranilic acid

2-aminoacetophenone

Downstream raw materials:

1-(2-Dimethylaminophenyl)-ethanol

1-methyl-1H-indole-2,3-dione