1-Chloro-n,n-dimethylmethanamine

Base Information

• Chemical Name: 1-Chloro-n,n-dimethylmethanamine
• CAS No.: 30438-74-5
• Molecular Formula: C3H8 Cl N
• Molecular Weight: 93.5562
• Hs Code.: 2921199090
• NSC Number: 97326
• DSSTox Substance ID: DTXSID60952778
• Nikkaji Number: J1.131.049D
• Wikidata: Q82931463
• Mol file: 30438-74-5.mol

Synonyms:1-chloro-n,n-dimethylmethanamine;30438-74-5;(CHLOROMETHYL)DIMETHYLAMINE;NSC97326;Methanamine, 1-chloro-N,N-dimethyl-;dimethylamino chloromethane;dimethylaminomethyl chloride;DTXSID60952778;IYMYHZHCOOWPGK-UHFFFAOYSA-N;AMY39211;NSC-97326;AKOS006383592

Chemical Property of 1-Chloro-n,n-dimethylmethanamine

Chemical Property:

• Vapor Pressure: 129mmHg at 25°C
• Melting Point: 140-145 °C
• Boiling Point: 70.3°Cat760mmHg
• PKA: 6.03±0.28(Predicted)
• Flash Point: °C
• PSA: 3.24000
• Density: 0.967g/cm³
• LogP: 0.74430
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 93.0345270
• Heavy Atom Count: 5
• Complexity: 20.9

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCl

Technology Process of 1-Chloro-n,n-dimethylmethanamine

There total 13 articles about 1-Chloro-n,n-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-<(trimethylsiloxy)methyl>dimethylamine (80202-60-4) → Hexamethyldisiloxane (107-46-0) + N-(chloromethyl)dimethylamine (30438-74-5)

Guidance literature:

With chloro-trimethyl-silane; In diethyl ether; at 20 - 40 ℃;

Reference yield: 95.0%

bis-(dimethylamino)methane (51-80-9) → N-(chloromethyl)dimethylamine (30438-74-5)

Guidance literature:

With acetyl chloride; In diethyl ether; for 2h; Ambient temperature;

Reference yield: 86.0%

chloro-trimethyl-silane (75-77-4) + C10H28N2O3Si2 (1446511-97-2) → decamethyltetrasiloxane (141-62-8) + N-(chloromethyl)dimethylamine (30438-74-5)

Guidance literature:

In benzene; at 40 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1021/om301206c

upstream raw materials:

bis-(dimethylamino)methane

sulfuric acid chloromethyl ester-methyl ester

dimethyl amine

N-<(trimethylsiloxy)methyl>dimethylamine

Downstream raw materials:

ortho-dimethylaminomethylphenol

1,2,4,5-Tetramethoxy-3-dimethylaminomethylbenzol

(E)-4-Phenyl-but-3-en-2-one O-dimethylaminomethyl-oxime

1,3-Dimethoxy-2-dimethylaminomethylbenzol

Refernces

• 1、 Sharma, Hemant K.,Arias-Ugarte, Renzo,Tomlinson, David,Gappa, Rie,Metta-Magana, Alejandro J.,Ito, Haruhiko,Pannell, Keith H.. "(Me3N)Mo(CO)5-catalyzed reduction of DMF by disiloxane and disilane moieties: Fate of the silicon-containing fragments". . p. 3788 - 3794. Retrieved 2013/08/23.
• 2、 Kozyukov, V. P.,Kozyukov, Vik. P.,Mironov, V. F.. "DEDISILOXANATION REACTION (ELIMINATION OF DISILOXANE) IN THE REACTIONS OF N-(SILOXYMETHYL) DERIVATIVES OF AMINES AND AMIDES WITH CHLORO-, (ACYLOXY)-, AND AMINO-SILANES". . p. 100 - 106. Retrieved 2007/10/02.