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STRYCHNINE

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STRYCHNINE

EINECS 200-319-7
CAS No. 57-24-9 Density 1.42g/cm3
PSA 32.78000 LogP 2.09540
Solubility negligible Melting Point 284-286 °C(lit.)

Formula C21H22 N2 O2 Boiling Point 559.9°Cat760mmHg
Molecular Weight 334.418 Flash Point 292.4°C
Transport Information UN 1692 Appearance white crystals or powder
Safety Human poison by ingestion. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. An allergen. Lethal dose to man: 30–60 mg/kg. If ingested, the time of action depends upon the condition of the stomach, whether empty or full, and the nature of the food present. If taken by subcutaneous injection, the place of administration of the injection will affect the time of action. The first symptoms are a feeling of uneasiness with a heightened reflex of irritability, followed by muscular twitching in some parts of the body. With larger doses, this is followed by a sense of impending suffocation. Convulsive movements begin that have the effect of mechanically causing the patient to cry out or to shriek; then follow the characteristic spasms, which set in with violence. These are at first clonic and then tonic. There are successive attacks of spasms. With each successive attack, the symptoms become more violent, eventually resulting in death. A rodenticide. When heated to decomposition it emits toxic fumes of NOx.

Analytical Methods:

   

For occupational chemical analysis use NIOSH: Strychnine, 5016.

Risk Codes R27/28;R50/53   
Molecular Structure Molecular Structure of 57-24-9 (STRYCHNINE) Hazard Symbols
Synonyms

Strychnine(8CI);4,6-Methano-6H,14H-indolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline,strychnidin-10-one deriv.; (-)-Strychnine; Certox; NSC 5365; Strychnin

Article Data 25

STRYCHNINE Chemical Properties

Synonyms: 2,4a,5,5a,7,8,15,15a,15b,15c-decahydro-4,6-methano-6h,14h-indolo[3,2,1-ij]oxep;
(-)-STRYCHNINE;STRYCHNINE;Strychnidin-10-one;STRYCHNINE ALKALOID;Vauquline;L-STRYCHNINE;
STRYCHNINE(57-24-9) is the chemical compound with the formula C21H22N2O2.Its molar mass is 334.41,and melting point 284-286 °C.
The Molecular Structure  of  STRYCHNINE(57-24-9):

STRYCHNINE History

In 1818,Strychnine(57-24-9) was first isolated from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou . Its structure was determined by Sir Robert Robinson and Herman Leuchs in 1946. In 1952, Robinson wrote that "For its molecular size it is the most complex substance known."

STRYCHNINE Toxicity Data With Reference

The  toxicity of  STRYCHNINE(57-24-9):
1.   

ims-rat TDLo:500 µg/kg (5D preg):REP

   PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 100 (1959),555.
2.   

orl-hmn LDLo:30 mg/kg

   PCOC**    Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc. (Topeka, KS.: )1966,1073.
3.   

orl-man LDLo:30 mg/kg

   PEMNDP    Pesticide Manual. 9 (1991),771.
4.   

orl-man LDLo:5143 mg/kg

   JTCTDW    Journal of Toxicology, Clinical Toxicology. 30 (1992),269.
5.   

orl-rat LD50:2350 µg/kg

   JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 31 (1942),113.
6.   

ipr-rat LD50:1100 µg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 58 (1936),239.
7.   

scu-rat LD50:1200 µg/kg

   RPTOAN    Russian Pharmacology and Toxicology. Translation of FATOAO. 31 (1968),260.
8.   

ivn-rat LD50:582 µg/kg

   CHHTAT    Zhonghua Yixue Zazhi. Chinese Medical Journal. 54 (1974),234.
9.   

orl-mus LD50:2 mg/kg

   IJEBA6    Indian Journal of Experimental Biology. 19 (1981),1075.
10.   

ipr-mus LD50:980 µ


STRYCHNINE Consensus Reports

Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

STRYCHNINE Safety Profile

Human poison by ingestion. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. An allergen. Lethal dose to man: 30–60 mg/kg. If ingested, the time of action depends upon the condition of the stomach, whether empty or full, and the nature of the food present. If taken by subcutaneous injection, the place of administration of the injection will affect the time of action. The first symptoms are a feeling of uneasiness with a heightened reflex of irritability, followed by muscular twitching in some parts of the body. With larger doses, this is followed by a sense of impending suffocation. Convulsive movements begin that have the effect of mechanically causing the patient to cry out or to shriek; then follow the characteristic spasms, which set in with violence. These are at first clonic and then tonic. There are successive attacks of spasms. With each successive attack, the symptoms become more violent, eventually resulting in death. A rodenticide. When heated to decomposition it emits toxic fumes of NOx.

STRYCHNINE Standards and Recommendations

The standards of  STRYCHNINE:
OSHA PEL: TWA 0.15 mg/m3
ACGIH TLV: TWA 0.15 mg/m3
DFG MAK: 0.15 mg/m3
DOT Classification:  6.1; Label: Poison

STRYCHNINE Analytical Methods

The analyticalmethods of  STRYCHNINE(57-24-9): For occupational chemical analysis use NIOSH: Strychnine, 5016.
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