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Sodium borohydride

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Name

Sodium borohydride

EINECS 241-004-4
CAS No. 16940-66-2 Density 1.035 g/mL at 25 °C
PSA 0.00000 LogP -1.45160
Solubility Water: 550 g/L (25 °C) Melting Point >300 °C (dec.)(lit.)
Formula NaBH4 Boiling Point 500oC
Molecular Weight 37.8325 Flash Point 69 °C
Transport Information UN 3129 4.3/PG 3 Appearance white solid
Safety 22-26-36/37/39-43A-45 Risk Codes 15-23/24/25-34
Molecular Structure Molecular Structure of 16940-66-2 (Sodium borohydride) Hazard Symbols FlammableF,ToxicT
Synonyms

Sodium tetrahydroborate(1-);Sodium borohydride (Na(BH4));Hidkitex DF;Sodium Borohydride, granular;Sodium Borohydride, powder;Sodium borohydride(SBH);sodium tetrahydroborate;

Article Data 196

Sodium borohydride Synthetic route

121-43-7

Trimethyl borate

7646-69-7

sodium hydride

16940-66-2

sodium tetrahydroborate

Conditions
ConditionsYield
Heating;99.5%
In neat (no solvent) 1mol B(OCH3)3, 4mol NaH, 225-275°C;; 90-96% NaBH4;;94%
In neat (no solvent) 1mol B(OCH3)3, 4mol NaH, 225-275°C;; 90-96% NaBH4;;94%

boric acid trimethylester tetrahydrofuranate

Tetrahydro-furan; compound with trifluoroborane

7646-69-7

sodium hydride

16940-66-2

sodium tetrahydroborate

Conditions
ConditionsYield
In tetrahydrofuran byproducts: NaF; addn. of B(OCH3)3*THF to NaH at 60-65°C (stirring, N2-atmosphere), NaH dissolves, boiling, cooling to ambient temp., addn. of BF3*THF, distn. of THF and B(OCH3), extractn. of residue with isopropyl amine;; pure product;;99%
In tetrahydrofuran byproducts: NaF; addn. of B(OCH3)3*THF to NaH at 60-65°C (stirring, N2-atmosphere), NaH dissolves, boiling, cooling to ambient temp., addn. of BF3*THF, distn. of THF and B(OCH3), extractn. of residue with isopropyl amine;; pure product;;99%

neodymium borohydride * 3 tetrahydrofuran

disodium 5,6-dihydro-1,4-dithiine-2,3-dithiolate

A

16940-66-2

sodium tetrahydroborate

B

[Na3(tetrahydrofuran)1.5Nd(5,6-dihydro-1,4-dithiine-2,3-dithiolate)3]

Conditions
ConditionsYield
In tetrahydrofuran (Ar); a flask charged with Nd complex, THF condensed, C4H4S2(SNa)2 added, stirred for 3 d at 20°C; filtered, evapd., extd. (THF), filtered; obtained impure;A n/a
B 99%
7646-69-7

sodium hydride

19287-45-7

diborane

16940-66-2

sodium tetrahydroborate

Conditions
ConditionsYield
In further solvent(s) react. of NaH with B2H6 in alkylene glycol dialkylether at 35-75°C;;98%
In tetrahydrofuran in abs. tetrahydrofurane; 4 h, under shaking; good yield; Na(BH4) suspension distilled, filtered and dried in oil pump vacuum at 130°C; purity = 97.5 %;93%
In tetrahydrofuran in abs. tetrahydrofurane; 4 h, under shaking; good yield; Na(BH4) suspension distilled, filtered and dried in oil pump vacuum at 130°C; purity = 97.5 %;93%
110-18-9

N,N,N,N,-tetramethylethylenediamine

NaZn(BH4)3*3DME

A

16940-66-2

sodium tetrahydroborate

B

N,N,N',N'-tetramethylethylenediaminebis(tetrahydroborate)zinc(II)

Conditions
ConditionsYield
In benzene org. compd. soln. addn. dropwise (magnetic stirring) to Zn-complex soln., NaBH4 ppt. filtration off after 1 h, solvent evapn. from filtrate (vac.); residue washing (pentane), drying (vac.); elem. anal; thermal anal.;A 77%
B 97%
109-63-7

trifluoroborane diethyl ether

7646-69-7

sodium hydride

A

16940-66-2

sodium tetrahydroborate

B

19287-45-7

diborane

Conditions
ConditionsYield
In diethylene glycol method for preparation of diborane, addn. of BF3-etherate (frehly distd.) to NaH in diglyme;;A n/a
B 92%
In diethylene glycol method for preparation of diborane, addn. of BF3-etherate (frehly distd.) to NaH in diglyme;;A n/a
B 92%
In diethyl ether at 110°C, method for preparation of diborane;;
In diethyl ether at 110°C, method for preparation of diborane;;

borax

1333-74-0

hydrogen

1310-73-2

sodium hydroxide

16940-66-2

sodium tetrahydroborate

Conditions
ConditionsYield
magnesium In water byproducts: MgO; process starts from borax and NaOH by exothermal steam process (H2O); dread at 270°C; H2 at surface of Mg particles generated protide to form NaBH4; process dependent on of rate temp. change, size of Mg particles; XRD;90%
7637-07-2

boron trifluoride

7646-69-7

sodium hydride

16940-66-2

sodium tetrahydroborate

Conditions
ConditionsYield
With catalyst: Na-alcoholate In neat (no solvent) passing BF3 over NaH in presence of a Na-alcoholate, 250-300°C;;90%
In neat (no solvent) byproducts: B2H6; on passing a mixture of BF3 and H2 (ratio=1:2) over powdered NaH at about 180°C;;
In diethyl ether react. of NaH with a soln. of BF3 in ether in an autoclave (about 10 at), 24h, about 120°C;;
In mineral oil at 250-265°C;; washing with petroleum ether, extractn. of NaBH4 from the residue with liquid NH3 at -33°C;;
In neat (no solvent) byproducts: B2H6; on passing a mixture of BF3 and H2 (ratio=1:2) over powdered NaH at about 180°C;;

NaSm(BH4)4 * 4 dimethoxyethane

A

16940-66-2

sodium tetrahydroborate

B

[Sm(BH4)3(tetrahydrofuran)3]

Conditions
ConditionsYield
With tetrahydrofuran In neat (no solvent) byproducts: DME; 140-160°C, vac., 2 h; extn. (THF), filtration off of NaBH4, distn. off of solvent; elem. anal.;A n/a
B 89%
121-43-7

Trimethyl borate

7646-69-7

sodium hydride

A

16940-66-2

sodium tetrahydroborate

B

18024-69-6

sodium tetramethoxyborate

Conditions
ConditionsYield
In tetrahydrofuran with excess NaH; at 65°C;A 83%
B n/a
In tetrahydrofuran on boiling in THF, pptn. of NaBH4;;
In tetrahydrofuran on boiling in THF, pptn. of NaBH4;;

Sodium borohydride Chemical Properties

Empirical Formula: H4BNa
Molecular Weight: 37.8325 g/mol
Flashing point: 69 °C
Density: 1.07 cm3
Melting point: 400 °C (dec.)
Storage tempreture: Store at RT.
Water solubility: 550 g/L (25 ºC)
Sensitive: Hygroscopic
Appearance: White solid
Structure of Sodium borohydride (CAS NO.16940-66-2):
                                  
Product Category of Sodium borohydride (CAS NO.16940-66-2): Inorganic Chemicals;Reduction;Synthetic Organic Chemistry;Typical Metal Compounds;Synthetic Reagents;Reducing Reagents

Sodium borohydride History

The compound was discovered in the 1940s by H. I. Schlessinger, who led a team that developed metal borohydrides for wartime applications.

Sodium borohydride Uses

 Sodium borohydride (CAS NO.16940-66-2) can be used as reducing agent of aldehyde, ketone, and chloride type , and  can be used for the foam in plastic industry, paper bleaching agent, as well as the hydrogenation agent of pharmaceutical industry manufacturing dihydrostreptomycin.

Sodium borohydride Production

The production likes:
H3BO3+3CH3OH→B(OCH3)3+3H2O
2Na+H2→2NaH
4NaH+B(OCH3)3→NaBH4+3CH3ONa

Sodium borohydride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LCLo inhalation 9mg/m3 (9mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
mouse LD50 oral 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
mouse LDLo intraperitoneal 18mg/kg (18mg/kg)   "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit LD50 oral 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
rabbit LD50 skin 230mg/kg (230mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
rabbit LDLo intraperitoneal 60mg/kg (60mg/kg)   "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit LDLo subcutaneous 300mg/kg (300mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
rat LC50 inhalation 36mg/m3 (36mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
rat LD50 intraperitoneal 18mg/kg (18mg/kg)   AMA Archives of Industrial Health. Vol. 17, Pg. 124, 1958.
rat LD50 oral 162mg/kg (162mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.
rat LD50 subcutaneous 177mg/kg (177mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999.

 Sodium borohydride (CAS NO.16940-66-2) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

Sodium borohydride Safety Profile

It is highly corrosive, and will cause burns upon contact with any area of the body.
Hazard Codes: FlammableF,ToxicT,DangerousN,CorrosiveC,HarmfulXn
Risk Statements: 60-61-15-34-23/24/25-24/25-35-21/22-51/53-42/43-49-63-62-36/38-43 
R15:Contact with water liberates extremely flammable gases. 
R21/22:Harmful in contact with skin and if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R34:Causes burns. 
R36/38:Irritating to eyes and skin. 
R42/43:May cause sensitization by inhalation and skin contact. 
R43:May cause sensitization by skin contact. 
R49:May cause cancer by inhalation. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R60:May impair fertility. 
R61:May cause harm to the unborn child.
Safety Statements: 53-43-45-43A-36/37/39-26-22-50-36/37 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S43:In case of fire use ... (there follows the type of fire-fighting equipment to be used.) 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S50:Do not mix with ... 
S53:Avoid exposure - obtain special instructions before use.

Sodium borohydride Specification

 Sodium borohydride , its cas register number is 16940-66-2. It also can be called Sodium tetrahydroborate ; Sodium borotritide ; and Sodium borohydrate . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Sodium borohydride (CAS NO.16940-66-2) could be stable under normal temperatures and pressures. It is not compatible with water, water, acids, alcohols, copper, halogenated agents, iron, sulfuric acid, dimethyl formamide, alkalies, nickel, palladium, aluminum chloride + bis(2-methoxyethyl) ether, diborane + bis(2-methoxyethyl) ether, ruthenium salts, anhydrous acids, polyglycols, dimethylacetamide, metal salts, trichlorosilane, aldehydes, activated carbon, ketones, heavy metals, and you must not take it with high temperatures, incompatible materials, ignition sources, excess heat, temperatures above 220 °C, and should be exposured to moist air or water. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide, oxides of boron, borane, hydrogen gas, sodium oxide.