CAS No.110-18-9,N,N,N',N'-Tetramethylethylenediamine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	110-18-9
Name:	N,N,N',N'-Tetramethylethylenediamine
Article Data:	83
Cas Database

Formula:	C₆H₁₆N₂
Molecular Weight:	116.206
Synonyms:	1,2-Ethanediamine,N,N,N',N'-tetramethyl- (9CI);Ethylenediamine, N,N,N',N'-tetramethyl-(6CI,8CI);(2-(Dimethylamino)ethyl)dimethylamine;1,2-Bis(dimethylamino)ethane;2,5-Dimethyl-2,5-diazahexane;Dabco TMEDA;Dimethyl[2-(dimethylamino)ethyl]amine;Kaolizer 11;MR;MR (amine);N,N,N',N'-Tetramethyl-1,2-diaminoethane;N,N,N',N'-Tetramethyl-1,2-ethanediamine;N,N,N',N'-Tetramethyl-1,2-ethylenediamine;Propamine D;TEMED;TMED;TMEDA;Tetrameen;Toyocat TE;
EINECS:	203-744-6
Density:	0.817 g/cm³
Melting Point:	-55 °C(lit.)
Boiling Point:	121 °C at 760 mmHg
Flash Point:	10 °C
Solubility:	miscible with water
Appearance:	Colorless to slightly yellow liquid
Hazard Symbols:	F,C
Risk Codes:	11-20/22-34-20/21/22
Safety:	16-26-36/37/39-45
Transport Information:	UN 2372 3/PG 2
PSA:	6.48000
LogP:	0.10960

Synthetic route

: 124-40-3
dimethyl amine

: 106-93-4
ethylene dibromide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In chloroform at 20℃; for 24h;	100%

: 124-40-3
dimethyl amine

: 74-86-2
acetylene

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With 1-ethyl-2-pyrrolidinone; sodium stannate(IV) trihydrate; alumina; calcium hydroxide at 45 - 80℃; for 6h; Reagent/catalyst; Temperature; Autoclave; Inert atmosphere;	98.6%

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With oxalic acid at 100 - 120℃; Eschweiler-Clarke methylation;	96%
With hydrogen In methanol at 130℃; under 15001.5 Torr; for 4.5h; Autoclave;	89%
With formic acid for 11h; Eschweiler-Clarke reaction; Reflux;	80%
at 130 - 160℃;
With water at 130 - 160℃; im Autoklaven;

: 67-56-1
methanol

: 107-15-3
ethylenediamine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With hydrogen at 180℃; under 7500.75 Torr;	91.6%
With hydrogen at 180℃; under 7500.75 Torr;	91.6%

: 89184-58-7
Li(1+)*((H3C)2NCH2)2*(C5H5)V(C3H5)2(1-)=(Li((H3C)2NCH2)2)((C5H5)V(C3H5)2)

: 201230-82-2
carbon monoxide

A: tetracarbonyl(η(5)-cyclopentadienyl)vanadium(I)

B: 592-42-7
1,5-Hexadien

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: dilithium (η-cyclopentadienyl)tri(carbonyl)vanadate

Conditions

Conditions	Yield
In tetrahydrofuran reaction of CO with (LiTMEDA)(CpV(C3H5)2) in THF (Ar); formation of 1,5-hexadiene in the reaction soln., extn. of the residue with toluene, filtering off the solid and drying to give Li2(CpV(CO)3), evapn. of the filtrate to dryness and subliming the residue in a high vacuum at 80°C to give CpV(CO)4;	A 91% B 46% C n/a D n/a

...Expand

: 366-18-7
[2,2]bipyridinyl

: [(N,N,N′,N′-tetramethylethylenediamine)Ni{CH2C(CH3)C(CH3)CH2COO}]

A: (CH2C(CH3)C(CH3)CH2COO)Ni((C5H4N)2)

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In diethyl ether vigorously stirring a suspension of (3,4,5-η3)-3,4-dimethyl-3-pentenylato-N,N,N',N'-tetramethylethylenediaminenickel(II) in ether with 2,2'-bipyridine (CO2 or Ar); filtn. of the formed brown yellow ppt. after 24 h, shaking with THF fora few hours, filtn. and washing the residue with ether, drying in vacuo, elem. anal.;	A 90% B n/a

...Expand

: Roussin's red salt dianion

: C6H16N2*2HNO(1-)*Fe(2+)

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: Fe4H2N8O8S2(2-)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.333333h; Inert atmosphere; Schlenk technique;	A n/a B 86%

...Expand

: 141-46-8
Glycolaldehyde

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With platinum on carbon; hydrogen In ethanol at 25℃; under 30003 Torr; for 12h; Solvent; Pressure; Reagent/catalyst; Autoclave;	A 84% B 8%
With 5%-palladium/activated carbon; hydrogen In ethanol at 25 - 80℃; under 30003 Torr; for 3h; Autoclave;	A 35% B 40%

...Expand

: 1020084-83-6
[4-Et(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[4-Et(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 83% C n/a

...Expand

: 1020084-88-1
[2-OMe(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[2-OMe(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 82% C n/a

...Expand

Raw Materials

106-93-4

5843-33-4

344-04-7

50-00-0

7699-64-1

59502-05-5

100-44-7

68661-11-0

Downstream Products

111-85-3

598-16-3

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Chemistry

Molecular formula: C₆H₁₆N₂
Molar mass: 116.24 g/mol
EINECS: 203-744-6
Index of Refraction: 1.437
Density: 0.817 g/cm³
Flash Point: 10 °C
Sensitive: Hygroscopic
Melting point: -55 °C(lit.)
Storage tempreture: Store at RT.
Water solubility: Miscible
Enthalpy of Vaporization: 35.91 kJ/mol
Boiling Point: 121 °C at 760 mmHg
Vapour Pressure: 14.9 mmHg at 25 °C
Solubility: H₂O: 10 mg/mL at 20 °C, clear, colorless
Appearance: Colorless to slightly yellow liquid
Structure of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9):

Product Category of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9): Biochemistry;Reagents for Electrophoresis

Uses

N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9) is widely used as a ligand for metal ions. It is used with ammonium persulfate to catalyze the polymerization of acrylamide when making polyacrylamide gels, and can be used in gel electrophoresis for the separation of proteins or nucleic acids.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	630mg/kg (630mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984.
quail	LD50	oral	> 316mg/kg (316mg/kg)		Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rabbit	LD50	skin	5390mg/kg (5390mg/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit	LD50	subcutaneous	1230mg/kg (1230mg/kg)		Toxicologist. Vol. 15, Pg. 19, 1995.
rat	LC50	inhalation	1318ppm/4H (1318ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: IRRITABILITY	Toxicologist. Vol. 8, Pg. 249, 1988.
rat	LD50	oral	268mg/kg (268mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES SPINAL CORD: OTHER DEGENERATIVE CHANGES	Toxicologist. Vol. 15, Pg. 19, 1995.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by ingestion. Mildly toxic by skin contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.
Hazard Codes: F, Corrosive C,Xi
Risk Statements: 11-20/22-34-20/21/22
R11:Highly flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R20/22:Harmful by inhalation and if swallowed.
R34:Causes burns.
Safety Statements: 16-26-36/37/39-45
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

Specification

N,N,N',N'-Tetramethylethylenediamine , its cas register number is 110-18-9. It also can be called 1,2-Di(dimethylamino)ethane ; TMEDA ; and TEMED . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.