Antibacterial spectrum

Synthesis QSAR (quantitative structure-activity relationship) Heterocyclic compounds Molecular docking Pharmacophore Cytotoxicity binding affinity antimicrobial agents Minimum inhibitory concentration (MIC) Enzyme inhibition In vitro Testing In Vivo Testing Biological Evaluation Lead Optimization Zone of Inhibition Virtual Screening Resistance Structure-Activity Relationship (SAR) Antiviral Activity Enzyme Kinetics Drug Resistance Drug Repurposing MIC Determination Bioavailability Mycobacterium tuberculosis In Silico Studies Antitubercular Agents Structure-Activity Relationship Metabolic Stability Antifungal Activity pKa Scaffold Hopping Toxicity Profile Bioisosteres Dependence Cephalosporins Quinazolinones Docking simulation Gram-positive bacteria Gram-negative bacteria MIC assay Drug-likeness β-lactamase ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Pharmacokinetics (PK) MTT assay Lipinski’s Rule of Five Docking score Ligand efficiency Selectivity index (SI)