Drug Repurposing

Synthesis NMR spectra Flash chromatography Silica gel QSAR (quantitative structure-activity relationship) Inhibitors Isocyanate TLC analysis Heterocyclic compounds Molecular docking Pharmacophore Cytotoxicity binding affinity antimicrobial agents Minimum inhibitory concentration (MIC) Enzyme inhibition In vitro Testing In Vivo Testing Biological Evaluation Lead Optimization Zone of Inhibition Combination Therapies Virtual Screening Resistance Structure-Activity Relationship (SAR) Antiviral Activity Enzyme Kinetics Drug Resistance Preclinical and Clinical Trials MIC Determination Bioavailability Mycobacterium tuberculosis In Silico Studies Antitubercular Agents Metabolic Stability Antifungal Activity Scaffold Hopping Toxicity Profile Bioisosteres Quinazolinones Docking simulation Gram-positive bacteria Gram-negative bacteria MIC assay Drug-likeness Antibacterial spectrum ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Pharmacokinetics (PK) MTT assay Lipinski’s Rule of Five