Quinazolinones

Heterocyclic compounds consisting of a benzene ring fused with a pyrimidine ring.

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Synthesis QSAR (quantitative structure-activity relationship) Heterocyclic compounds Alcohols Molecular docking Pharmacophore Cytotoxicity binding affinity antimicrobial agents Minimum inhibitory concentration (MIC) Enzyme inhibition In vitro Testing In Vivo Testing Biological Evaluation Lead Optimization Zone of Inhibition Virtual Screening Resistance Structure-Activity Relationship (SAR) Antiviral Activity Enzyme Kinetics Drug Resistance Drug Repurposing MIC Determination Bioavailability Mycobacterium tuberculosis In Silico Studies Antitubercular Agents Metabolic Stability Antifungal Activity Scaffold Hopping Toxicity Profile Bioisosteres Direct synthesis Docking simulation Gram-positive bacteria Gram-negative bacteria MIC assay Drug-likeness Antibacterial spectrum ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Pharmacokinetics (PK) MTT assay Lipinski’s Rule of Five Docking score Ligand efficiency Selectivity index (SI) MIC90 Tuberculosis (TB) Therapeutic index (TI)

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