Renin inhibitors

Synthesis Chiral Optimization Molecular modeling X-ray crystallography Design and Synthesis Potent Kinetic Analysis Experimental terms Experimental Novel Synthesis Biphenyl/diphenyl ether S1 pocket S3 pocket Filling the S1 pocket of renin via the S3 pocket Incorporation Assay C-Terminal Structure-based design Dipeptide Analogues Dehydrohydroxyethylene Isostere Scissile Bond Component 1,2,3-Trisubstituted Cyclopropanes Conformationally Restricted Peptide Isosteres Transition-state analogue inhibitors Phosphorus acid derivatives 5or 7-azaindole-scaffolds Unnatural (2S,3S)-tartaric acid (2S,3R,4S)-4-Amino-5-cyclohexyl-1-morpholino-2,3-pentanediol (2S,3R,4S)-2-Amino-1-cyclohexyl-6-methyl-3,4-heptandiol C-Terminal Components