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| CAS No.: | 76-25-5 |
|---|---|
| Name: | Triamcinolone acetonide |
| Molecular Structure: | |
|
|
|
| Formula: | C24H31FO6 |
| Molecular Weight: | 434.505 |
| Synonyms: | Aristocort A;Azmacort;Berlicort;Extracort;Kenacort 80;Kenacort A 40;Kenalog;Kenalog 10;Kenalog 40;Ledercort Cream;Lichtena;Nasacort;Respicort;Rineton;TAC 3;Tamceton;Tramacin;Tri-Nasal;Triacet;Triamcinolone 16,17-acetonide;Triamcort-Depot;Triamhexal;Trianopollon;Tricinolon;Vetalog;Vetazine;Volon A;Volonimat;Triamcinalone acetonide;Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-;9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9a-Fluoro-11b,21-dihydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione;9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;Adcortyl A;Aristocort acetonide; |
| EINECS: | 200-948-7 |
| Density: | 1.33 g/cm3 |
| Melting Point: | 274-278°C (dec.) |
| Boiling Point: | 576.9 °C at 760 mmHg |
| Flash Point: | 302.7 °C |
| Solubility: | Soluble in DMSO or ethanol. Slightly soluble in water. |
| Appearance: | White solid |
| Hazard Symbols: |
|
| Risk Codes: | 61 |
| Safety: | 53-45 |
| PSA: | 93.06000 |
| LogP: | 2.41880 |
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| Conditions | Yield |
|---|---|
| With boron trifluoride diethyl etherate at -10 - 0℃; | 93% |
| With hydrogenchloride for 1h; Heating; | 52% |
| With methanesulfonic acid at 50℃; for 2h; Temperature; |
- 64089-14-1
11β-trimethylsiloxy-21-acetoxy-16α,17α-isopropylidenedioxy-9α-fluoro-pregna-1,4-diene-3,20-dione
B
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| With sodium carbonate In aqueous hydrofluoric acid | A 80% B n/a |
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| With hydrogen fluoride In chloroform at -40℃; | 76% |
- 1524-86-3
16α-17-[(1-methylethylidene)bis(oxy)]-11β,21-dihydroxy-9-fluoro-4-ene-pregna-3,20-dione
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 70h; Heating; | 40% |
| Conditions | Yield |
|---|---|
| With perchloric acid; acetone | |
| With hydrogenchloride; acetone |
- 13951-70-7
desonide
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: pyridine 2: SOCl2; pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol 5: CHCl3; HF 6: methanol.KOH 7: acetone; hydrochloric acid View Scheme |
- 23460-76-6
21-acetoxy-pregna-4,9(11),16-triene-3,20-dinone
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: KMnO4 2: pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol / Behandeln einer Loesung des Reaktionsprodukts in Pyridin mit Acetanhydrid 5: CHCl3; HF 6: mit Hilfe von Nocardia corallina 7: methanol.KOH 8: acetone; hydrochloric acid View Scheme |
- 74220-43-2
21-Acetoxy-16α,17α-dihydroxy-4,9(11)-pregnadien-3,20-dion
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: pyridine 2: aqueous HClO4; dioxane 3: potassium acetate; ethanol / Behandeln einer Loesung des Reaktionsprodukts in Pyridin mit Acetanhydrid 4: CHCl3; HF 5: mit Hilfe von Nocardia corallina 6: methanol.KOH 7: acetone; hydrochloric acid View Scheme |
- 95943-95-6
16α,21-diacetoxy-17-hydroxy-pregna-1,4,9(11)-triene-3,20-dione
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: aqueous HClO4; dioxane 2: potassium acetate; ethanol 3: CHCl3; HF 4: methanol.KOH 5: acetone; hydrochloric acid View Scheme |
- 98422-55-0
16α,21-diacetoxyprednisolone
- 76-25-5
triamcinolone acetonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: SOCl2; pyridine 2: aqueous HClO4; dioxane 3: potassium acetate; ethanol 4: CHCl3; HF 5: methanol.KOH 6: acetone; hydrochloric acid View Scheme |
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
1. Introduction of Triamcinolone acetonide
Triamcinolone acetonide, with the Systematic Name of (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, is one kind of white solid. For being incompatible with strong oxidizing agents, it belongs to the Product Categories which include Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals. Besides, its Classification Code are including Adrenal Cortex Hormones; Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Immunologic Factors; Immunosuppressive agents; Mutation data; Reproductive Effect.
2. Properties of Triamcinolone acetonide
Triamcinolone acetonide has the below properties: (1)Molar Refractivity: 109.41 cm3; (2)Molar Volume: 324.8 cm3; (3)Surface Tension: 54.5 dyne/cm; (4)Density: 1.33 g/cm3; (5)Flash Point: 302.7 °C; (6)Enthalpy of Vaporization: 99.19 kJ/mol; (7)Boiling Point: 576.9 °C at 760 mmHg; (8)Vapour Pressure: 1.04E-15 mmHg at 25 °C; (9)Appearance: White Solid; (10)Melting Point: 274-278 °C (dec.).
3. Toxicity of Triamcinolone acetonide
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intramuscular | 571ug/kg (0.571mg/kg) | VASCULAR: SHOCK SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Pharmacotherpy. Vol. 28, Pg. 1310, 1994. |
| mouse | LD50 | intraperitoneal | 105mg/kg (105mg/kg) | Drugs in Japan Vol. 6, Pg. 516, 1982. | |
| mouse | LD50 | oral | 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. | |
| mouse | LD50 | subcutaneous | 132mg/kg (132mg/kg) | Drugs in Japan Vol. 6, Pg. 516, 1982. | |
| rat | LD50 | subcutaneous | 13100ug/kg (13.1mg/kg) | Drugs of the Future. Vol. 6, Pg. 44, 1981. | |
| women | TDLo | parenteral | 4mg/kg (4mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | Netherlands Journal of Medicine. Vol. 56, Pg. 12, 2000. |
4. Safety Information of Triamcinolone acetonide
Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F−.
Hazard Codes: 
T
Risk Statements: 61
R61:May cause harm to the unborn child.
Safety Statements: 53-45
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: TU3920000
5. Use and Preparation of Triamcinolone acetonide
Aristocort acetonide can be used as adrenal cortical hormone medicines and also used in neurodermatitis, eczema, psoriasis, joint pain, bronchial asthma and other illnesses.
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