10230-26-9Relevant articles and documents
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Traynham,J.G.,Lee,Y.-S.
, p. 3590 - 3594 (1974)
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VALISA: A new procedure for total lineshape analysis of NMR spectra. Conformational analysis of trans-1,2-dibromocyclopentane
Zubkov,Golotvin,Chertkov
, p. 1222 - 1230 (2002)
A new strategy of total lineshape analysis of the multiplet structure of NMR spectra was proposed and a VALISA program was developed to implement the computational procedure. Evaluation of the new technique taking a solution of several test problems and the complete analysis of the 1H NMR spectrum of trans-1,2-dibromocyclopentane as examples showed its high efficiency. Using a complete set of vicinal spin-spin coupling constants, detailed conformational analysis of this molecule was carried out and a more correct model for the description of conformational interconversions of the five-membered cycles was proposed. Conformational behavior of trans-1,2-dibromocyclopentane molecule can be reasonably described assuming large-amplitude molecular vibrations along a sector of the pseudorotation path, containing mostly diequatorial conformations.
Method for preparing o-dibromo compounds from olefins
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Paragraph 0012; 0013, (2018/09/28)
The invention relates to a method for preparing o-dibromo compounds from olefins, and the structural formulae of the o-dibromo compounds are as follows. The method comprises the following steps: dropwise adding a dichloromethane solution of dimethyl sulfoxide (1.5 equiv) into a dichloromethane solution of oxalyl bromide (1.5 equv) at a temperature of -10 DEG C, then dropwise adding a raw materialolefin, and then recovering the temperature to room temperature or carrying out heating to 30-40 DEG C, carrying out a reaction to obtain the corresponding o-dibromo compounds, wherein the yield is ina range of 79-97%.
PLATINUM COMPOUND OF MALONIC ACID DERIVATIVE HAVING LEAVING GROUP CONTAINING AMINO OR ALKYLAMINO
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Paragraph 0171, (2015/11/16)
Disclosed are a class of platinum compounds of malonic acid derivatives having a leaving group containing an amino or alkylamino, and pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition containing the compou