105409-39-0

Upstream product

• 105498-20-2 1-O-acetyl-sn-glycerol 
• 116-11-0 2-Methoxypropene 
• 75-36-5 acetyl chloride 
• 121348-86-5 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl acetate 
• 108-24-7 acetic anhydride 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 141-78-6 ethyl acetate 
• 64-19-7 acetic acid 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 6946-10-7 1,3-diacetoxyacetone 
• 108-05-4 vinyl acetate 
• 109429-01-8 (S)-2-(benzyloxy)-3-hydroxypropyl acetate 
• 105409-38-9 1,3-di-O-acetyl-2-O-benzylglycerol 

Downstream Products

• 14347-78-5 1,2-O-isopropylidene-D-glycerol 

Relevant academic research and scientific papers

Enantioselective hydrolysis of (RS)-isopropylideneglycerol acetate with Kluyveromyces marxianus

The hydrolysis of (RS)-isopropylideneglycerol acetate with whole cells of the yeast Kluyveromyces marxianus is reported. The biotransformation furnished (R)-isopropylideneglycerol as major enantiomer with good enantioselectivity (E=28) under optimised conditions. The reaction can be performed in an ultrafiltration-membrane reactor allowing for the obtainment of 19.2g/L of enantiomerically pure (R)-isopropylideneglycerol acetate starting from 60g/L of racemic mixture.

A genetic selection system for evolving enantioselectivity of enzymes

As an alternative to screening in the directed evolution of enantioselective enzymes, a selection system has been implemented for a lipase-catalyzed hydrolytic kinetic resolution of a chiral ester. The Royal Society of Chemistry.

Ethyl acetate as an acetyl surrogate for the iodine catalyzed acetylation of alcohols

The use of readily available ethyl acetate in the presence of iodine as an alternative acetylating agent is reported. Amines and phenols were unreactive under the examined reaction conditions, indicating that the method is highly chemoselective.

Lipases aided esterification of (2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Racemic solketal (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol 1, was treated with carboxylic acids of varying chain length or their vinyl esters in the presence of different lipases. The esterification reaction was carried out in n-hexane or diisopropyl ether as a solvent. The yield of the solketal esters and their enantiopurity were satisfactory, as indicated by gas chromatography using chiral column. Lipases from Rhizopus oryzae and Pseudomonas fluorescence gave the best enantiomeric excess (ee) when the solketal was treated with vinyl butyrate in a solution of diisopropyl ether at room temperature.