116782-25-3

Basic information

• Product Name: methyl 2-benzoylpropionate
• CAS NO: 116782-25-3
• Molecular Weight: 192.214
• Mol File: 116782-25-3.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: methyl 2-benzoylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzoylpropionate(116782-25-3)
• EPA Substance Registry System: methyl 2-benzoylpropionate(116782-25-3)

Safety Data

• Hazardous Substances Data: 116782-25-3(Hazardous Substances Data)

Upstream product

• 17639-93-9 2-chloro-propionic acid methyl ester 
• 100-52-7 benzaldehyde 
• 82111-78-2 methyl 2-benzoylprop-2-enoate 
• 673-32-5 1-Phenylprop-1-yne 
• 67-56-1 methanol 
• 554-12-1 propanoic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 614-45-9 tert-Butyl peroxybenzoate 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 36919-03-6 methyl pentafluorophenyl carbonate 
• 93-55-0 1-phenyl-propan-1-one 
• 93-97-0 benzoic acid anhydride 
• 292638-85-8 acrylic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 93-55-0 1-phenyl-propan-1-one 
• 1202873-88-8 C₂₂H₂₃ClN₄O₃ 
• 1202873-76-4 C₂₂H₂₂ClN₃O₄ 
• 765271-39-4 methyl 2-fluoro-2-methyl-3-oxo-3-phenylpropionate 
• 23244-37-3 4-methyl-3-phenylisoxazole-5(4H)-one 
• 94199-26-5 (2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 36041-80-2 (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 36041-79-9 (-)-(2R,3S)-3-hydroxy-2-methyl-3-phenylpropionic acid 
• 7087-77-6 (1S,2S)-2-methyl-1-phenyl-propane-1,3-diol 

Relevant articles and documents

A General and Robust Method for the Preparation of (E)- and (Z)-Stereodefined Fully Substituted Enol Tosylates: Promising Cross-Coupling Partners

A robust method for preparing (E)- and (Z)-stereodefined fully substituted enol tosylates is described. α-Substituted β-keto esters undergo (E)-selective enol tosylations using TsCl-Me2N(CH2)6NMe2 as the reagent (method A, 13 examples; 63-96%) and (Z)-selective enol tosylations using TsCl-TMEDA-LiCl as the reagent (method B, 13 examples; 62-99%). A plausible mechanism for the (E)- and (Z)-enol tosylation selectivity is proposed. A 1H NMR monitoring experiment revealed that TsCl coupled with TMEDA formed a simple N-sulfonylammonium intermediate.

Radical Chlorodifluoromethylation: Providing a Motif for (Hetero)arene Diversification

A method for the radical chlorodifluoromethylation of (hetero)arenes using chlorodifluoroacetic anhydride is reported. This operationally simple protocol proceeds under mild photochemical conditions with high functional group compatibility and complements the large body of literature for the trifluoromethylation of (hetero)arenes. Introduction of the chlorodifluoromethyl motif enables rapid diversification to a wide array of aromatic scaffolds. This work showcases the chlorodifluoromethyl group as an attractive entryway to otherwise synthetically challenging electron-rich difluoromethyl(hetero)arenes. Furthermore, facile conversion of the CF2Cl moiety into the corresponding aryl esters, gem-difluoroenones, and β-keto-esters is demonstrated.

Palladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high atomic economy due to no elimination of CO2 occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies. (Figure presented.).

Asymmetric Alkynylation of β-Ketoesters and Naphthols Promoted by New Chiral Biphenylic Iodanes

The preparation of new chiral biphenylic λ3-iodane reagents bearing transferable alkynyl ligands is described. These reagents transfer their carbon-based ligands onto β-ketoesters with an enantiomeric excess (ee) up to 68 %, and most remarkably, enable the dearomative alkynylation of naphthols in good to high yields up to 84 % ee.