1191-16-8Relevant articles and documents
Isoprene related esters, significant components of Pandanus tectorius
Vahirua-Lechat,Menut,Roig,Bessiere,Lamaty
, p. 1277 - 1279 (1996)
Isopentenyl and dimethylallyl acetates and cinnamates have been found in large amounts in an essential oil obtained from the ripe fruit of Pandanus tectorius, their identification has been confirmed by synthesis. This is the first time that these esters, apart from one, have been found in the plant kingdom and, generally speaking, that monoterpene precursors predominate in an essential oil.
A NEW PATHWAY FOR THE SYNTHESIS OF 2,2-DIMETHYL-3,3-DICHLOROCYCLOPROPANECARBOXYLIC ACID
Kryshtal, G. V.,Yanovskaya, L. A.,Volkov, Yu. P.
, p. 620 - 622 (1987)
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Paterno-Buechi reactions of allylic alcohols and acetates with aldehydes: Hydrogen-bond interaction in the excited singlet and triplet states? [2]
Griesbeck,Bondock
, p. 6191 - 6192 (2001)
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Evaluation of gem-Diacetates as Alternative Reagents for Enzymatic Regio-and Stereoselective Acylation of Alcohols
Koszelewski, Dominik,Brodzka, Anna,Madej, Arleta,Trzepizur, Damian,Ostaszewski, Ryszard
, p. 6331 - 6342 (2021/05/06)
Geminal diacetates have been used as sustainable acyl donors for enzymatic acylation of chiral and nonchiral alcohols. Especially, it was revealed that geminal diacetates showed higher reactivity than vinyl acetate for hydrolases that are sensitive to acetaldehyde. Under optimized conditions for enzymatic acylation, several synthetically relevant saturated and unsaturated acetates of various primary alcohols were obtained in very high yields up to 98% without E/Z isomerization of the double bond. Subsequently, the acyl donor was recreated from the resulting aldehyde and reused constantly in acylation. Therefore, the developed process is characterized by high atomic efficiency. Moreover, it was shown that acylation using geminal diacetates resulted in remarkable regioselectivity by discriminating among the primary and secondary hydroxyl groups in 1-phenyl-1,3-propanediol providing exclusively 3-acetoxy-1-phenyl-propan-1-ol in good yield. Further, enzymatic kinetic resolution (EKR) and chemoenzymatic dynamic kinetic resolution (DKR) protocols were developed using geminal diacetate as an acylating agent, resulting in chiral acetates in high yields up to 94% with enantiomeric excesses exceeding 99%.
Preparation method of 4-acetoxy-2-methyl-2-butenal
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, (2020/09/30)
The invention provides a preparation method of a vitamin A intermediate, namely 4-acetoxy-2-methyl-2-butenal. The method comprises the following steps: (1) carrying out ring opening on 3-methyl-1,2-epoxybutane under the action of alkaline acetate to generate 2-hydroxyl-3-butyl methyl acetate; (2) dehydrating 2-hydroxyl-3-butyl methyl acetate to obtain 3-methyl-2-butene acetate; and (3) carrying out one step selective oxidation on 3-methyl-2-butenyl acetate to obtain 4-acetoxy-2-methyl-2-butenal. According to the method, 3-methyl-1,2-epoxybutane is used as an initial raw material, the reactionsynthesis route is short, the atom economy is high, the operation is simple, and the method is an industrially optimized synthesis route.
Method for preparing 4-acetoxy-2-methyl-2-butenal
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Paragraph 0019; 0046; 0047; 0049; 0050; 0052-0053; 0055-0056, (2020/04/29)
The invention provides a method for preparing 4-acetoxy-2-methyl-2-butenal. The method comprises the following steps: esterifying isopentenol to generate isopentenol acetate; and carrying out illumination oxidation on the isopentenol acetate in the presence of a photosensitizer to generate 4-acetoxy-2-methyl-2-butenal. The method has the advantages of cheap and easily available starting raw material isopentenol, high atom economy of the process route, no use of precious metals, less three wastes, and economic and effective synthesis route.