13148-19-1

Upstream product

• 15856-60-7 2,3-epoxy-2-methyl-1,3-diphenyl-propan-1-one 
• 110-54-3 hexane 
• 109-63-7 trifluoroborane diethyl ether 
• 5351-09-7 (E)-1-phenylprop-1-en-2-yl benzoate 
• 451-40-1 phenyl benzyl ketone 
• 108-24-7 acetic anhydride 
• 98-88-4 benzoyl chloride 
• 5876-69-7 2,4-diphenylbut-3-yn-2-ol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 39689-94-6 deoxybenzoin sodium enolate 
• 75-36-5 acetyl chloride 
• 71-43-2 benzene 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 51463-88-8 3-Methyl-4,5-diphenylpyrazole 
• 198470-84-7 parecoxib 
• 37928-17-9 5-methyl-3,4-diphenyl isoxazole 
• 181695-72-7 valdecoxib 

Relevant academic research and scientific papers

Ion-size recognition of Group 13 metals (Al3+, In3+) with modified β-diketones

Ion-size recognition of Group 13 metals (Al3+ and In3+) with modified β-diketones, 3-phenylpentane-2,4-dione (α-phenylacetylacetone, HL2) and 1,2-diphenylbutane-1,3-dione (α-phenylbenzoylacetone, HL4), has been

A process for the preparation of the handkerchief auspicious past cloth method

The invention discloses a method for preparing parecoxib. The method comprises the following steps: an initial raw material 3-oxo-2-phenylbutanoyl chloride and benzene undergo a Friedel-Crafts reaction to generate 1,2-diphenylbutane-1,3-dione, 1,2-diphenylbutane-1,3-dione is sulfonated by chlorosulfonic acid or concentrated sulfuric acid/acetyl chloride to obtain 4-(1,3-dioxo-1-phenylbutyl-2-yl)-1-sulfonyl chloride, 4-(1,3-dioxo-1-phenylbutyl-2-yl)-1-sulfonyl chloride is acted by ammonia water to generate 4-(1,3-dioxo-1-phenylbutyl-2-yl)-1-sulfonamide, and 4-(1,3-dioxo-1-phenylbutyl-2-yl)-1-sulfonamide reacts with propionic anhydride or propionyl chloride to obtain N-(4-(1,3-dioxo-1-phenylbutyl-2-yl)phenylsulfonyl)propionamide, N-(4-(1,3-dioxo-1-phenylbutyl-2-yl)phenylsulfonyl)propionamide undergoes condensation by using hydroxylamine hydrochloride to synthesize a ring, and dehydration is carried out under an acidic condition to obtain parecoxib. The parecoxib is prepared from 3-oxo-2-phenylbutanoyl chloride as the initial raw material through the Friedel-Crafts reaction, a sulfonation reaction, an amidation reaction and a condensation reaction. The method has the advantages of low cost of the initial raw material, simple process, low requirements of reaction conditions, simple post-treatment operation, high product yield and purity, and realization of large-scale production.

A method of preparing intermediates handkerchief auspicious past cloth sodium

The invention discloses a novel method for preparing a parecoxib sodium intermediate 5-methyl-3, 4-diphenyl isoxazole. The method comprises the following steps: performing rearrangement reaction on a compound in the formula I (referring to the Specification)under the action of a catalyst to prepare a compound in the formula II(referring to the Specification); and under the condition of a catalyst, reacting hydroxylammonium chloride with the compound in the formula II to prepare 5-methyl-3,4-diphenyl isoxazole. The method disclosed by the invention has the advantages of mild reaction condition, good simplicity and convenience for operation, low cost, environmental-friendliness and the like.

Enolate anionic initiator, sodium deoxybenzoin, for leading living natures by formation of aggregators at the growth chain ends

The living anionic polymerization of n-hexyl isocyanate (HIC) using a newly developed initiator forming metal-enolate complex, sodium deoxybenzoin (Na-DB), is reported. For the polymerization of HIC, Na-DB serves the dual functions of providing controlled

Tandem carbon-carbon bond insertion and intramolecular aldol reaction of benzyne with aroylacetones: Novel formation of 4,4′-disubstituted 1,1′-binaphthols

An efficient route to 4-aryl-2-naphthols from arynes and aroylacetones was developed by carbon-carbon bond insertion followed by an intramolecular aldol reaction and dehydration. Benzyne derived from 2-(trimethylsilyl)phenyl triflate reacted with benzoyla

Regioselectivity switch: Gold(I)-catalyzed oxidative rearrangement of propargyl alcohols to 1,3-diketones

The gold(I)-catalyzed oxidative rearrangement of propargyl alcohols provides an efficient and selective route to 1,3-diketones under mild conditions. Pyridine-N-oxides were used as external oxidants with, different from related substrates, no alkylidenecycloalkanones or oxetan-3-ones formed as side-products.

Reactions of copper(II) β-diketonates under free radical conditions. II. Diazonium salts as aryl radicals source in the arylation of β-diketones

Copper complexes of 2,2,6,6-tetramethylheptane-3,5-dione and other β-diketones afford α-aryl-β-diketones when treated with arenediazonium tetrafluoroborates and copper powder in dichloromethane.