14305-29-4

Basic information

• Product Name: 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane
• Synonyms: 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane
• CAS NO: 14305-29-4
• Molecular Weight: 194.274
• Mol File: 14305-29-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane(14305-29-4)
• EPA Substance Registry System: 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane(14305-29-4)

Safety Data

• Hazardous Substances Data: 14305-29-4(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 104-20-1 4-(4-methoxyphenyl)-2-butanone 
• 75-89-8 2,2,2-trifluoroethanol 
• 23020-47-5 3-chloro-1-(4-methoxyphenyl)-3-methylbutane 
• 18491-21-9 1-methoxy-4-(3-methylbut-3-en-1-yl)benzene 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 943-88-4 4-(p-methoxyphenyl)-3-butene-2-one 
• 84384-30-5 4-(4-methoxyphenyl)-2-methyl-3-butyn-2-ol 
• 637-69-4 4-Methoxystyrene 
• 110-12-3 5-Methyl-2-hexanone 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 75-16-1 methylmagnesium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 4957-18-0 1-methoxy-4-(3-methyl-but-2-enyl)benzene 
• 18491-21-9 1-methoxy-4-(3-methylbut-3-en-1-yl)benzene 
• 184779-69-9 1-Methoxy-4-[3-methyl-3-(2,2,2-trifluoro-ethoxy)-butyl]-benzene 
• 1615227-20-7 2-(4-(4-methoxyphenyl)-2-methylbutan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 66265-81-4 1-(4-Hydroxy-3-methanesulfonyl-phenyl)-2-[3-(4-methoxy-phenyl)-1,1-dimethyl-propylamino]-ethanone 
• 85981-68-6 5-(4-Methoxyphenyl)-3,3-dimethyl-1,2-dioxolan 
• 85981-59-5 3-(4-Methoxyphenyl)-1,1-dimethylpropylhydroperoxid 
• 23020-47-5 3-chloro-1-(4-methoxyphenyl)-3-methylbutane 
• 66265-34-7 1,1-dimethyl-3-(4-methoxyphenyl)propylamine 

Relevant articles and documents

Ligand-Free Nickel-Catalyzed Reductive Allylic Defluorinative Cross-Coupling of α-Trifluoromethyl Alkenes with Epoxides

We report a reductive allylic defluorinative reaction of α-trifluoromethyl alkenes with terminal epoxides, which consists of an iodide-mediated regioselective ring opening and a nickel-catalyzed radical-type cross-coupling, providing diverse tertiary gem -difluorobishomoallylic alcohols in moderate to high yields. Notably, this reaction is conducted under mild conditions and requires no external ligand or proton donor.

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Aqueous phase semihydrogenation of alkynes over Ni-Fe bimetallic catalysts

Bimetallic Ni-Fe catalysts (Ni/Fe, 1?:?1, 1?:?3, and 3?:?1) are synthesized and explored for their catalytic activity in semihydrogenation of internal alkynes using H2 gas in water-ethanol solution. Our findings revealed that over the Ni1Fe3 catalyst a high diastereoselectivity for Z-alkenes with a high conversion for a wide range of internal alkynes can be achieved at moderate reaction temperature (40 °C). Notably, the selectivity for the Z-alkenes is enhanced in the presence of n-butyl amine as an additive. Deuterium labeling experiments evidenced that H2 gas becomes dissociated homolytically over the catalyst surface to hydrogenate alkynes to alkenes. Synthesized catalysts were successfully characterized by HR-TEM, SEM, XPS, EDS, P-XRD and H2-TPD.