1485-72-9

Basic information

• Product Name: N-BENZHYDRYL-BENZAMIDE
• Synonyms: N-BENZHYDRYL-BENZAMIDE
• CAS NO: 1485-72-9
• Molecular Formula: C₂₀H₁₇NO
• Molecular Weight: 287.36
• Mol File: 1485-72-9.mol
• Article Data: 86

Chemical Properties

• Boiling Point: 512°Cat760mmHg
• Flash Point: 310°C
• Appearance: /
• Density: 1.129g/cm³
• Vapor Pressure: 1.34E-10mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: N-BENZHYDRYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZHYDRYL-BENZAMIDE(1485-72-9)
• EPA Substance Registry System: N-BENZHYDRYL-BENZAMIDE(1485-72-9)

Safety Data

• Hazardous Substances Data: 1485-72-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 10, p. 927, 1969 DOI: 10.1017/S0009838800024678

InChI:InChI=1/C20H17NO/c22-20(18-14-8-3-9-15-18)21-19(16-10-4-1-5-11-16)17-12-6-2-7-13-17/h1-15,19H,(H,21,22)

Upstream product

• 100727-40-0 nitric acid benzhydryl ester 
• 55-21-0 benzamide 
• 91-01-0 1,1-Diphenylmethanol 
• 100-47-0 benzonitrile 
• 844-40-6 diphenylmethanol trifluoroacetate 
• 67-56-1 methanol 
• 58-72-0 Triphenylethylene 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 98-88-4 benzoyl chloride 
• 91-00-9 Benzhydrylamine 
• 776-74-9 Bromodiphenylmethane 
• 101-81-5 Diphenylmethane 
• 1575-95-7 N-acetylbenzamide 
• 954-67-6 benzhydryl acetate 

Downstream Products

• 65-85-0 benzoic acid 
• 62506-88-1 N-benzylidenediphenylmethanamine 
• 5467-43-6 1,3,3-triphenylpropyne 
• 1409940-90-4 2-benzhydryl-3-octyl-3H-inden-5-yl-4-methylbenzenesulfonate 
• 19672-37-8 3-benzhydryl-pentane-2,4-dione 
• 1013-88-3 Benzophenone imine 
• 100-47-0 benzonitrile 
• 90-99-3 diphenylchloromethane 
• 1585-45-1 N-(diphenylmethylene)benzamide 

Relevant articles and documents

Rhodium-catalyzed arylation and alkenylation of imines with organostannanes

A rhodium complex catalyzed the addition of aryl- and alkenyl-stannanes to activated aldimines under mild and neutral conditions, affording the corresponding amines in good yields.

An expedient, efficient and solvent-free synthesis of T3P-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation

An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent yields under the given conditions (26 examples, 68-93% yield).

Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Preparation method of photocatalytic N-alkylamide compound

The invention belongs to the technical field of organic synthesis, and provides a preparation method of an N-alkylamide compound. According to the method, a dioxazolone compound and an alkane derivative are used as raw materials, a manganese catalyst and an additive react for 12-24 hours in an organic solvent under a mild condition under photocatalysis, and the product is converted into an N-alkylamide compound. The method has the beneficial effects that the raw materials are cheap and easy to obtain, the conditions are mild, the method is environment-friendly, the possibility of industrialization is realized, and the yield of the N-alkylamide compound is high; the N-alkylamide compound can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.