16513-74-9

Upstream product

• 93-99-2 benzoic acid phenyl ester 
• 98-88-4 benzoyl chloride 
• 108-95-2 phenol 
• 7446-70-0 aluminium trichloride 
• 75-75-2 methanesulfonic acid 
• 122-79-2 Phenyl acetate 
• 62-53-3 aniline 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 98-07-7 Benzotrichlorid 
• 98-95-3 nitrobenzene 
• 71-43-2 benzene 
• 1137-42-4 4-Hydroxybenzophenone 
• 117-99-7 2-Hydroxybenzophenone 

Downstream Products

• 113736-78-0 4-Benzoyloxy-benzophenondichlorid 
• 65-85-0 benzoic acid 
• 1137-42-4 4-Hydroxybenzophenone 
• 108-95-2 phenol 
• 94465-11-9 α-Oxy-4-benzoyloxy-diphenylmethan 
• 530-48-3 1,1-Diphenylethylene 
• 645-49-8 cis-stilben 
• 113736-79-1 α,α'-Bis(4-benzoyloxyphenyl)-stilben 
• 80232-65-1 (E/Z)-1,2-bis-(4-hydroxyphenyl)-1,2-diphenylethylene 
• 113736-80-4 α,α'-Diphenyl-stilbenchinon (4,4') 
• 83887-62-1 4-benzoylphenyl methane sulfonate 
• 2589-81-3 (4-hydroxy-1,3-phenylene)bis(phenylmethanone) 

Relevant academic research and scientific papers

Benzophenone esters and sulfonates: Synthesis and their potential as antiinflammatory agents

Background: Inflammation is a biological rejoinder of vascular tissues against destructive agents e.g. irritants, damaged cell or pathogens. During inflammation, respiratory burst occurs by activated phagocytes which help to destroy invading pathogens. Ph

CH3SO3H/P2O5 (4:1) as an efficient reagent for the one-pot synthesis of acylaryl methane sulfonates of phenolic

Methansulfonic acid/di-phosphorus pentoxide (4:1) was found to be an efficient reagent for one-pot synthesis of acylaryl methane sulfonates of phenolic esters via Fries rearrangement. This method is easy, rapid, and high-yielding reactions for the synthesis of acylaryl methane sulfonates.

Methanesulfonic acid/phosphorus oxychloride (MAPO) as a new efficient reagent in the fries rearrangement

Methanesulfonic acid/phosphorus oxychloride (MAPO) was found to be a new efficient reagent in the Fries rearrangement of phenolic esters. Fries rearrangement of phenolic esters in the presence of MAPO, gave acylaryl methane sulfonates as major products.

A REEXAMINATION OF THE RETRO-FRIES REARRANGEMENT OF SOME o-HYDROXYKETONES

The retro-Fries rearrangement, catalyzed by protic and Lewis acids, was studied for some o-hydroxyketones.The results are consistent with the mechanism of an heterolytic cleavage and rearrangement.It appears that, in general, Lewis acids do not induce the retro-Fries rearrangement of o-hydroxyketones.However, in certain cases, it may be brought about the presence of a protic acid generated in situ, from a solvent-catalyst interaction.

The Fries Rearrangement as an Equilibrium Reaction

The Fries rearrangement of arylbenzoates 1, in 1,2-dichloroethane in the presence of trifluoromethanesulfonic acid (TFMS) as catalyst, to ortho- and para-hydroxyaryl ketones (2 and 3, resp.) is reversible at 170 deg C; an equilibrium of the compounds 1, 2, and 3 is established.The equilibrium is achieved starting from the aryl esters 1 as well as from the hydroxyaryl ketones 2 and 3, respectively.The higher stability of the ortho-compounds 2 compared to the para-compounds 3 can be explained by greater resonance interaction between the carbonyl group and the aromatic ring in 2.The torsion angles Θ, which are good indicators of this interaction, can be determined from 13C NMR spectra.A dissociative mechanism is proposed for the acryl group migration.