17005-59-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 106-48-9 4-chloro-phenol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1121-74-0 potassium 4-chlorophenoxide 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 18297-63-7 N,N'-bis(trimethylsilyl)urea 
• 13154-24-0 triisopropylsilyl chloride 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 4039-32-1 lithium hexamethyldisilazane 
• 108-90-7 chlorobenzene 
• 54380-53-9 cyclohexa-2,5-dien-1-yl(trimethyl)silane 

Downstream Products

• 18036-81-2 trimethyl-(4-trimethylsilanyloxy-phenyl)-silane 
• 18415-47-9 ethyl-[4-(ethyl-dimethyl-silanyloxy)-phenyl]-dimethyl-silane 
• 18588-84-6 dimethyl-bis-(4-trimethylsilanyloxy-phenyl)-silane 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 41605-52-1 4-chlorophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 75-77-4 chloro-trimethyl-silane 
• 41231-41-8 p-Chlorphenyl-methansulfinat 
• 52602-11-6 2-(4-chlorophenyloxy)-2-methyl-4H-1,3-benzodioxin-4-one 
• 52602-12-7 2-Acetoxy-benzoic acid 4-chloro-phenyl ester 
• 1529-17-5 phenyltrimethylsilyl ether 
• 876-27-7 4-chlorophenyl acetate 
• 2005-08-5 4-chlorophenyl benzoate 
• 2915-36-8 α,ω-bis(4-hydroxyphenyl)dimethylsilane 
• 18401-68-8 (CH₃)3SiOC₆H₄Si(CH₃)2(C₂H₅) 

Relevant academic research and scientific papers

Regioselectivity of Hydroxyl Radical Reactions with Arenes in Nonaqueous Solutions

The regioselectivity of hydroxyl radical addition to arenes was studied using a novel analytical method capable of trapping radicals formed after the first elementary step of reaction, without alteration of the product distributions by secondary oxidation processes. Product analyses of these reactions indicate a preference for o- over p-substitution for electron donating groups, with both favored over m-addition. The observed distributions are qualitatively similar to those observed for the addition of other carbon-centered radicals, although the magnitude of the regioselectivity observed is greater for hydroxyl. The data, reproduced by high accuracy CBS-QB3 computational methods, indicate that both polar and radical stabilization effects play a role in the observed regioselectivities. The application and potential limitations of the analytical method used are discussed.

Application of a novel nano-immobilization of ionic liquid on an MCM-41 system for trimethylsilylation of alcohols and phenols with hexamethyldisilazane

3-[(3-(Trisilyloxy)propyl)chloride]-1-methylimidazolium tribromide ionic liquid supported on MCM-41 [nano-MCM-41@(CH2)3-1-methylimidazole]Br3 as a novel heterogeneous nano-catalyst was easily prepared and characterized usi

Activation of hexamethyldisilazane (HMDS) by TiO2 nanoparticles for protection of alcohols and phenols: the effect of the catalyst phase on catalytic activity

Anatase TiO2 nanoparticles (TiO2 NPs) were synthesized by the sol–gel method using titanium tetra-isopropoxide (TTIP), isopropyl alcohol, and distilled water and then calcined at 400?°C for 3?h. X-ray diffraction and scanning electron microscopy methods, and Fourier transform infrared spectroscopy were used for characterization of the obtained TiO2 NPs. The obtained anatase TiO2 NPs were used as heterogeneous catalyst for trimethylsilation of various alcohols or phenols with hexamethyldisilazane (HMDS) in CH3CN at room temperature. High to quantitative yields of the products were obtained within short reaction times at room temperature using a very low loading of pure TiO2 NPs without any post-modification with Bronsted or Lewis acid species such as ClSO3H or HClO4. The catalyst can be recycled at least three times without significant loss of its activity. The results of this study provide evidence that the pure anatase phase of TiO2 exhibits higher catalytic activity in terms of catalyst loading and required reaction time compared to a mixture of anatase and rutile phases found in the commercial samples for trimethylsilation of various alcohols or phenols with HMDS.

Nano Fe3O4@ZrO2/SO42?: A highly efficient catalyst for the protection and deprotection of hydroxyl groups using HMDS under solvent-free condition

In this work, we introduce a new procedure for the protection and deprotection process of various types of alcohols and phenols by HMDS in the presence of nano magnetic sulfated zirconia (Fe3O4@ZrO2/SO42?) as a solid acid catalyst under very mild and solvent-free condition. This method has interesting advantages like short reaction times and a simple workup process. With regard to some outstanding benefits of this new heterogeneous catalyst such as excellent yield, reusability of the catalyst and easy thermal stability, high acidity, strong and excellent magnetic properties, this method can be very interesting in aspect of green chemistry Principles.

Graphene oxide-bound electron-deficient tin(IV) porphyrin: a highly efficient and selective catalyst for trimethylsilylation of alcohols and phenols with hexamethyldisilazane

The catalytic activity of graphene oxide-bound tetrakis(p-aminophenyl)porphyrinatotin(IV) trifluoromethanesulfonate, [SnIV(TNH2PP)(OTf)2], in the trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) is reported. The prepared catalyst was characterized using inductively coupled plasma analysis, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared and diffuse reflectance UV–visible spectroscopies. This heterogeneous catalyst was used for selective trimethylsilylation of various alcohols and phenols with HMDS in short reaction times and high yields. Also, the catalyst is of high reusability and stability, in that it was recovered several times without loss of its initial activity. The chemoselectivity of this catalytic system in the silylation of primary alcohols in the presence of secondary and tertiary alcohols and also phenols was investigated.

Chlorozincate(II) acidic ionic liquid: Efficient and biodegradable silylation catalyst

A practical and highly efficient silylation of alcohol and phenol derivatives with hexamethyldisilazane (HMDS) using acidic ionic liquids under mild reaction conditions is described. A series of Br?nsted as well as Br?nsted–Lewis acidic ionic liquids were prepared and their performance investigated for the silylation of a wide variety of alcohols and phenols with HMDS. Imidazole- as well as N-methyl-2-pyrrolidone-based acidic ionic liquids have a higher catalytic activity for the protection of sensitive, hindered alcohols and phenols, thus providing an environmentally begin and versatile alternative to current acid catalysts. In addition, the acidic ionic liquids are reusable, being recovered easily and reused several times without significant deterioration in catalytic activity.

P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines

P4VPy–CuO nanoparticles were synthesized using ultrasound irradiations. Relevant properties of the synthesized nanoparticles were investigated by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. After identification, the prepared reagent was used for the promotion of different types of protection reactions of alcohols, phenols and amines. Easy workup, short reaction times, excellent yields, relatively low cost and reusability of the catalyst are the striking features of the reported methods.

Highly efficient protection of alcohols and phenols catalysed by tin porphyrin supported on MIL-101

The catalytic activity of 5,10,15,20-tetrakis(4-aminophenyl)porphyrinatotin(IV) trifluoromethanesulfonate, [SnIV(TNH2PP)(OTf)2], supported on chloromethylated MIL-101, was investigated in the trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) and also their tetrahydropyranylation with 3,4-dihydro-2H-pyran. Excellent yields, mild reaction conditions, short reaction times and reusability of the catalyst without significant decrease in its initial activity are noteworthy advantages of this supported catalyst.

TENOFOVIR PRODRUG AND PHARMACEUTICAL USES THEREOF

The invention relates to a tenofovir prodrug and pharmaceutical uses thereof. In particular, the invention relates to a compound as shown in general formula (I) and its isomer, pharmaceutically acceptable salt, hydrate or solvate, as well as their uses in

Selective silylation of alcohols, phenols and oximes using N-chlorosaccharin as an efficient catalyst under mild and solvent-free conditions

Efficient silylation of OH group in alcohols, phenols and oximes is described using a catalytic amount of N-chlorosaccharin and hexamethyldisilazane (HMDS) under mild and solvent-free conditions. This silylation reaction can be carried out with excellent and interesting various selectivities.