1838-59-1 Usage
Description
Allyl formate (CAS # 1838-59-1) is a clear, colorless liquid. It is
slightly soluble in water. It is reported to cause liver and kidney
injury in animals. The most common effect in humans
following occupational exposure to allyl formate exposure is
upper respiratory tract irritation.
Uses
Allyl formate is used as a solvent in spray lacquers, enamels, varnishes, and
latex paints and as an ingredient in paint thinners and strippers,
varnish removers, and herbicides. It is also used in liquid soaps,
cosmetics, industrial and household cleaners, and dry-cleaning
compounds.
General Description
A colorless liquid. Soluble in water. Flash point between 5 and 67°F. Highly toxic by ingestion, inhalation and skin contact.
Air & Water Reactions
Highly flammable. Soluble in water.
Reactivity Profile
ALLYL FORMATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health Hazard
TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Poison by ingestion. Moderately toxic by inhalation. Very flammable and reactive. Dangerous fire hazard. See also ALLYL COMPOUNDS and ESTERS. When heated to decomposition it yields irritating smoke and fumes
Environmental Fate
Allyl formate is cleaved by nonspecific esterases to allyl alcohol,
which is then oxidized by alcohol dehydrogenases to the
reactive acrolein, which is responsible for the hepatotoxic
action. The toxicity of allyl alcohol via its metabolite acrolein is
dependent on the concentration of GSH. After depletion of
GSH, the reactive metabolite of allyl alcohol can bind to
essential sulfhydryl groups in the cellular macromolecules,
leading to structural and functional modifications, which can
be responsible for hepatic injury. Appearance of lipid peroxidation
signals events that follow toxication mechanisms
initiated by acrolein, and subsequent and continued lipid
peroxidation could be merely the consequence of the cell
death.
Check Digit Verification of cas no
The CAS Registry Mumber 1838-59-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,3 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1838-59:
(6*1)+(5*8)+(4*3)+(3*8)+(2*5)+(1*9)=101
101 % 10 = 1
So 1838-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O2/c1-2-3-6-4-5/h2,4H,1,3H2
1838-59-1Relevant articles and documents
Substituent Effects on the Aliphatic Claisen Rearrangement. 1. Synthesis and Rearrangement of Cyano-Substituted Allyl Vinyl Ethers
Burrows, Cynthia J.,Carpenter, Barry K.
, p. 6983 - 6984 (1981)
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PROCESS FOR THE PRODUCTION OF ALLYL COMPOUNDS BY DEOXYDEHYDRATION OF GLYCEROL
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Paragraph 0062, (2018/09/20)
The present invention concerns acontinuous-flow process for the production of allyl compounds by deoxydehydration of glycerol comprising the following steps: (a)Forming a reactive solution by mixing glycerol (1) with: ?a carboxylic acid (2), and/or ?a triethyl orthoester, preferably triethyl orthoformate (TEOF); (b)Feeding the reactive solution to an inlet of a channel of a thermolysis microreactor module wherein the channel has an inner hydraulic diameter, D=4A/P, wherein A is the area and P the perimeter of a cross-section of the channel, of not more than 1000μm, (c)Exposing the reactive solution to thermolysis by driving a flow of the reactive solution along the channel from the inlet to an outlet, for a thermolysis time, t, at a pressure, P, and at a thermolysis temperature, T, larger than 200°C, to form thermolysis products including at least one allyl compound; and Recovering the thermolysis products at the outlet and separating the at least one allyl compound from the other thermolysis products
Method for preparing allyl alcohol
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Page/Page column 4; 5, (2015/09/23)
Disclosed is a method for preparing allyl alcohol, wherein glycerol and formic acid are reacted under specific synthesis conditions, thus remarkably increasing the concentration of allyl alcohol in the liquid reaction products and minimizing the production of allyl formate byproduct and the production of unreacted formic acid.
