1856-05-9

Usage

Uses

Used in Analytical Chemistry:
O-Trimethylsilylcholesterol is used as an internal standard for mass spectrometry and chromatography techniques. It aids in the accurate quantification and identification of cholesterol and related compounds in biological samples.
Used in Biological Research:
O-Trimethylsilylcholesterol is utilized in the study of cholesterol metabolism across various biological systems. Its stable nature ensures reliable measurements and analysis of cholesterol levels in different research contexts.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, O-Trimethylsilylcholesterol may be employed as a reference compound for the development and validation of assays and tests related to cholesterol and its metabolic pathways, ensuring the accuracy and reliability of such diagnostic tools.

Upstream product

• 57-88-5 cholesterol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1066-40-6 Trimethylsilanol 
• 75-77-4 chloro-trimethyl-silane 
• 601-54-7 Cholest-5-en-3-one 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 54380-53-9 cyclohexa-2,5-dien-1-yl(trimethyl)silane 
• 4039-32-1 lithium hexamethyldisilazane 
• 21149-38-2 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide 
• 53296-64-3 N-methyl-N-trimethylsilyl-heptafluoro-butyramide 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 18297-63-7 N,N'-bis(trimethylsilyl)urea 
• 57-88-5 cholesterol 

Downstream Products

• 41736-89-4 3-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)cholesterol 
• 70753-59-2 O-[2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl]cholesterol 
• 601-57-0 Cholest-4-en-3-one 
• 604-35-3 Cholesteryl acetate 
• 601-54-7 Cholest-5-en-3-one 
• 95898-07-0 3β-cholesteryl 2,3,4-tri-O-benzyl-β-D-xylopyranoside 
• 95898-07-0 3β-cholesteryl 2,3,4-tri-O-benzyl-α-D-xylopyranoside 

Relevant academic research and scientific papers

Selective silylation of alcohols, phenols and oximes using N-chlorosaccharin as an efficient catalyst under mild and solvent-free conditions

Efficient silylation of OH group in alcohols, phenols and oximes is described using a catalytic amount of N-chlorosaccharin and hexamethyldisilazane (HMDS) under mild and solvent-free conditions. This silylation reaction can be carried out with excellent and interesting various selectivities.

Determination of total cholesterol in serum by gas chromatography-mass spectrometry

In this study, a reliable protocol for determination of total cholesterol in serum using gas chromatography-mass spectrometry was established. The total free cholesterol was extracted from the serum with chloroform and derivatized with bis(trimethylsilyl)trifluoroacetamide, analyzed without the saponification step commonly used. Linear calibration curves of cholesterol were obtained from the concentration 0.1 to 15 mmol L-1. The limit of detection was 0.04 mmol L-1. Finally, the proposed method was to explore the influence of high cholesterol diet on total cholesterol in serum of rats.

Salt-free preparation of trimethylsilyl ethers by B(C6F 5)3-catalyzed transfer silylation by using a Me 3SiH surrogate

An unprecedented transfer silylation of alcohols catalyzed by the strong Lewis acid B(C6F5)3 is described. Gaseous Me3SiH is released in situ by B(C6F5) 3-catalyzed decomposition of 3-trimethylsilylcyclohexa-1,4-diene and subsequently reacts with an alcohol in a dehydrogenative Si-O coupling promoted by the same boron catalyst. Benzene and dihydrogen are formed during the reaction, but no salt waste is. This expedient protocol is applicable to several silicon groups, and the preparation of trimethylsilyl ethers presented here is potentially useful for alcohol derivatization prior to GLC analysis. Copyright

Highly atom economical uncatalysed and I2-catalysed silylation of phenols, alcohols and carbohydrates, using HMDS under solvent-free reaction conditions (SFRC)

An uncatalysed silylation of phenols, regardless on the aggregate state and nature of the substituents with 0.55 equiv of HMDS under solvent-free reaction conditions (SFRC) at room temperature is reported. Sterically hindered phenols, carbohydrates and most of the alcohols additionally required a catalytic amount (up to 2 mol %) of iodine. The reaction protocol is very simple; obtaining a pure product, particularly of uncatalysed reactions, was frequently a completely solvent-free process.

Alum: An efficient catalyst for trimethylsilylation of alcohols and phenols with hexamethyldisilazane

A highly convenient method for the trimethylsilylation of alcohols and phenols via treatment by hexamethyldisilazane in the presence of alum as a catalyst has been developed. A wide variety of hydroxyl groups were selectively protected in CH3CN under mild conditions.

Polyvinylpolypyrrolidoniume tribromide as new and metal-free catalyst for the formylation and trimethylsilylation of hydroxyl group

Trimethylsilylation of alcohols was achieved using 1,1,1,3,3,3- hexamethyldisilazane (HMDS) as silylating agent, in the presence of polyvinylpolypyrrolidoniume tribromide in acetonitrile at room temperature. Also a variety of alcohols were converted into alkyl formates by ethyl formate and a catalytic amount of polyvinylpolypyrrolidoniume tribromide under solvent free conditions at room temperature.

Protection of hydroxyl groups as a trimethylsilyl ether by 1,1,1,3,3,3-hexamethyldisilazane promoted by aspartic acid as an efficient organocatalyst

A wide variety of alcohols and phenols were protected as trimethylsilyl ethers using 1,1,1,3,3,3-hexamethyl disilazane catalyzed by aspartic acid as a non-toxic, metal-free, and green organocatalyst at room temperature in acetonitrile under mild and heterogeneous conditions. The procedure is operationally simple and the silylated product was obtained in high yield and purity.

Melamine-trisulfonic-acid-catalyzed trimethylsilylation of alcohols and phenols

A highly convenient method for the trimethylsilylation of alcohols and phenols via treatment by hexamethyldisilazane in the presence ofmelamine trisulfonic acid as a catalyst has been developed. A wide variety of hydroxyl groups were selectively protected under solvent-free conditions. Copyright Taylor & Francis Group, LLC.

Chemoselective and catalytic trimethylsilylation of alcohols and phenols by 1,1,1,3,3,3-hexamethyldisilazane and catalytic amounts of PhMe 3N+Br3-

An efficient procedure for the trimethylsilylation of alcohols and phenols is presented. The combination of 1,1,1,3,3,3-hexamethyldisilazane and a catalytic amount of phenyltrimethylammonium tribromide (PhMe3N +Br3-) was found to be effective for the trimethylsilylation of alcohols and phenols. The protection reaction is very simple and homogenously performed in dichloromethane at room temperature and mild conditions.

Nutritional traits of bean (Phaseolus vulgaris) seeds from plants chronically exposed to ozone pollution

The effect of chronic exposure to ozone pollution on nutritional traits of bean (Phaseolus vulgaris L. cv. Borlotto Nano Lingua di Fuoco) seeds from plants grown in filtered and nonfiltered open-top chambers (OTCs) has been investigated. Results showed th